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A murine model of SCD was studied to determine the effects of the SGLT\u20102 inhibitor, empagliflozin, on anaemia and stroke size. The University of Michigan's Precision Health Database was used to evaluate the effect of SGLT\u20102 inhibitors on anaemia in humans with SCD. SCD mice treated with daily empagliflozin for 8\u2009weeks demonstrated increases in haemoglobin, haematocrit, erythrocyte counts, reticulocyte percentage and erythropoietin compared to vehicle\u2010treated mice. Following photochemical\u2010induced thrombosis of the middle cerebral artery, mice treated with empagliflozin demonstrated reduced stroke size compared to vehicle treated mice. In the electronic health records analysis, haemoglobin, haematocrit and erythrocyte counts increased in human SCD subjects treated with an SGLT\u20102 inhibitor. SGLT\u20102 inhibitor treatment of humans and mice with SCD is associated with improvement in anaemic parameters. Empagliflozin treatment is also associated with reduced stroke size in SCD mice suggesting SGLT\u20102 inhibitor treatment may be beneficial with regard to both anaemia and vascular complications in SCD patients.<\/jats:p>","DOI":"10.1111\/jcmm.70091","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T03:46:56Z","timestamp":1726199216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inhibition of sodium\u2010glucose cotransporter\u20102 improves anaemia in mice and humans with sickle cell disease, and reduces infarct size in a murine stroke model"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9223-8493","authenticated-orcid":false,"given":"Jintao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Cardiovascular Research Center University of Michigan  Ann Arbor Michigan 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