{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:09:16Z","timestamp":1784257756361,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010814","name":"Anhui Provincial Department of Education","doi-asserted-by":"publisher","award":["KJ2019ZD25"],"award-info":[{"award-number":["KJ2019ZD25"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Provincial Department of Education","doi-asserted-by":"publisher","award":["KJ2020A0200"],"award-info":[{"award-number":["KJ2020A0200"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The expression of the long noncoding RNA (lncRNA) TPTE pseudogene 1 (TPTEP1) is significantly downregulated in ovarian cancer (OC). However, the function and mechanism of the lncRNA TPTEP1 in OC have not been identified. To investigate the expression of the lncRNA TPTEP1, we analysed a publicly available dataset and 20 pairs of OC and normal ovarian samples tissue from the First Affiliated Hospital of Anhui Medical University. Functional assays were used to determine the role of the lncRNA TPTEP1 in OC progression. Furthermore, Western blot, FISH, RNA pull\u2010down, mass spectrometry and RNA immunoprecipitation approaches were used to determine the mechanism by which the lncRNA TPTEP1 affects OC progression. Animal experiments were used to determine the role of the lncRNA TPTEP1 in ovarian tumorigenicity in\u00a0vivo. The expression of the lncRNA TPTEP1 in OC tissues was significantly lower than that in normal tissues and low expression of the lncRNA TPTEP1 was significantly correlated with advanced FIGO stage and the presence of malignant ascites in OC patients. In\u00a0vitro and in\u00a0vivo, regulation of the expression of the lncRNA TPTEP1 caused changes in OC cell proliferation, migration, invasion and apoptosis. Mechanistically, we found that TPTEP1 directly binds to the polypyrimidine tract\u2010binding protein 1 (PTBP1) protein and inhibits PI3K\/AKT signalling. The lncRNA TPTEP1 inhibits PI3K\/AKT signalling by directly binding PTBP1, possibly indicating the molecular mechanism underlying its biological function. With further research, these findings may aid in the development of clinically useful strategies for the treatment of OC.<\/jats:p>","DOI":"10.1111\/jcmm.70106","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T14:00:15Z","timestamp":1729260015000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The <scp>lncRNA TPTEP1<\/scp> suppresses <scp>PI3K<\/scp>\/<scp>AKT<\/scp> signalling and inhibits ovarian cancer progression by interacting with <scp>PTBP1<\/scp>"],"prefix":"10.1111","volume":"28","author":[{"given":"Yifan","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract Anhui Medical University  Hefei Anhui China"},{"name":"Key Laboratory of Population Health Across Life Cycle Anhui Medical University Ministry of Education of the People's Republic of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract Anhui Medical University  Hefei Anhui China"},{"name":"Key Laboratory of Population Health Across Life Cycle Anhui Medical University Ministry of Education of the People's Republic of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"Anhui Province Key Laboratory of Reproductive Health and Genetics  Hefei Anhui 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