{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:35:16Z","timestamp":1782228916858,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110487; 2023A1515110981"],"award-info":[{"award-number":["2023A1515110487; 2023A1515110981"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073464"],"award-info":[{"award-number":["82073464"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human papillomavirus (HPV) infection can cause condyloma acuminatum (CA), which is characterized by a high incidence and a propensity for recurrence after treatment. Angiogenesis plays an important role in the occurrence and development of CA. Seryl\u2010tRNA synthetase (SerRS) is a newly identified, potent anti\u2010angiogenic factor that directly binds to the vascular endothelial growth factor (VEGFA) promoter, thereby suppressing its transcription. Emodin is a natural anthraquinone derivative that can promote SerRS expression. This study aimed to investigate the effects of emodin on CA and explore combined treatment strategies. The HPV\u2010infected cell line SiHa was treated with either DMSO, emodin, ALA\u2010PDT or a combination of emodin and ALA\u2010PDT. We observed the effects on cell proliferation, apoptosis and the SerRS\u2010VEGFA pathway. Our findings demonstrated that emodin targets angiogenesis through the SerRS\u2010VEGFA pathway, resulting in the inhibition of SiHa cell proliferation and promotion of apoptosis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). To verify the therapeutic effect of emodin combined with ALA\u2010PDT on HPV\u2010associated tumours in\u00a0vivo, we established an animal xenograft model by subcutaneously inoculating mice with SiHa cells (<jats:italic>n<\/jats:italic>\u2009=\u20094). The results showed that the combination of emodin and ALA\u2010PDT significantly inhibited the expression of VEGFA to inhibit angiogenesis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), thus showing an inhibitory effect on tumour (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Furthermore, we determined that the mechanism underlying the decrease in VEGFA expression after emodin combined with ALA\u2010PDT in CA may be attributed to the promotion of SerRS expression (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The combination of emodin and ALA\u2010PDT holds promise as a novel therapeutic target for CA by targeting neovascularization in condyloma tissues.<\/jats:p>","DOI":"10.1111\/jcmm.70122","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T08:33:47Z","timestamp":1727771627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Emodin combined with 5\u2010aminolevulinic acid photodynamic therapy inhibits condyloma acuminate angiogenesis by targeting <scp>SerRS<\/scp>"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0369-7582","authenticated-orcid":false,"given":"Hongyan","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Nanfang Hospital Southern Medical University  Guangzhou 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