{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T04:44:14Z","timestamp":1778301854960,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alcohol liver disease has become a worldwide critical health problem. The ingested alcohol could be converted into acetaldehyde or combined with free fatty acids to induce the endoplasmic reticulum oxidative stress in the liver. Coincidentally, AKR7A5 has both aldehyde detoxification and antioxidant effects. Therefore, we discuss the possible role and mechanism of AKR7A5 in the acute alcohol injury of mice liver. There were four experiment groups, the C57BL\/6 mice of wild\u2010type mice (WT) or AKR7A5\u2212\/\u2212 mice (KO) were intragastrically administrated with saline or 50% ethanol at 14\u2009mL\/kg, respectively. Compared to the WT\u2009+\u2009alcohol group, abnormal liver function, disordered hepatic cord, severe congestion in the hepatic sinus and the space of the hepatic cord, occurrence of oxidative stress, DNA damage and different expressions of apoptosis\u2010related proteins were detected in the KO\u2009+\u2009alcohol group. Meanwhile, the biological process enrichment analysis showed that the down\u2010regulated proteins were related to the metabolism of fatty acid, the up\u2010regulated proteins positive regulation of reactive oxygen species metabolic process, negative regulation of coagulation and haemostasis. In conclusion, single ethanol binge combined with the absence of AKR7A5 caused more severe inflammatory response, oxidative stress, apoptosis of endogenous pathways, abnormal lipids metabolism and disordered coagulation in mice liver.<\/jats:p>","DOI":"10.1111\/jcmm.70129","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T13:56:39Z","timestamp":1728050199000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>AKR7A5<\/scp> knockout promote acute liver injury by inducing inflammatory response, oxidative stress and apoptosis in mice"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3857-5647","authenticated-orcid":false,"given":"Hui","family":"Shi","sequence":"first","affiliation":[{"name":"College of Life Science Yantai University  Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenda","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Life Science Yantai University  Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingling","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Science Yantai University  Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Science Yantai University  Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silin","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Life Science Yantai University  Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenjun","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Life Science Yantai University  Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960170"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i45.5063"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.10.020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-7364-3-4-362"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.03.015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2024.110896"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(02)02982-4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0009-2797(02)00173-4"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.068023"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00559-5"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annhyg\/meh015"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.06.004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.06.013"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2014.02.010"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8030050"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)63473-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2004.10.005"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i47.17756"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304058"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2022.10.002"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci24282"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214377"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.020"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.09.028"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1615\/critreveukargeneexpr.v8.i2.60"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12033"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2022.02.005"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.032"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2012.08.004"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13840"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27036"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.70129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T07:14:01Z","timestamp":1728976441000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.70129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":31,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/jcmm.70129"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.70129","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70129"}}