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Metastasis at secondary sites requires that cancer cells develop anoikis resistance to survive during circulation. High levels of bone sialoprotein (BSP), a member of the small integrin\u2010binding ligand N\u2010linked glycoproteins (SIBLINGs), have been shown to promote the spread of lung cancer cells; however, the effects of BSP in anoikis resistance are largely unknown. In this study, we determined that BSP promotes anoikis resistance in lung cancer cells. BSP was also shown to promote the expression of E\u2010cadherin and vimentin (epithelial\u2010to\u2010mesenchymal transition markers, which have been utilized as indicators of anoikis resistance). It appears that BSP facilitates MMP\u201014\u2010dependent anoikis resistance by inhibiting the synthesis of miR\u2010150\u20105p and activating the ERK signalling pathway. Knockdown of BSP expression was shown to block lung cancer metastasis by lowering anoikis resistance <jats:italic>in vivo<\/jats:italic>. These results indicate that BSP is a promising target to deal with anoikis resistance and metastasis in human lung cancers.<\/jats:p>","DOI":"10.1111\/jcmm.70155","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T16:40:32Z","timestamp":1730133632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Bone sialoprotein facilitates anoikis resistance in lung cancer by inhibiting <scp>miR<\/scp>\u2010150\u20105p expression"],"prefix":"10.1111","volume":"28","author":[{"given":"Le Huynh Hoai","family":"Thuong","sequence":"first","affiliation":[{"name":"Graduate Institute of Biomedical Sciences China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Lun","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of General Thoracic Surgery, Department of Surgery Changhua Christian Hospital  Changhua 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