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In this study, we isolated a new antioxidant molecule from the sun coral <jats:italic>Tubastraea tagusensis<\/jats:italic> and analysed it in cells exposed to oligomeric amyloid\u2010beta peptide 1\u201042 (oA\u03b242). The coral was collected and immersed in methanol for the release of compounds, which were submitted to antioxidant DPPH and FRAP activity\u2010guided fractionation using solid\u2010phase extraction and HPLC. An active pure molecule was analysed by mass spectrometry and tested in SH\u2010SY5Y differentiated neurons previously exposed to 5\u2009\u03bcM oA\u03b242. The isolated active molecule was identified as tubastrine, which could significantly inhibit the cell death caused by the amyloid peptide. Moreover, oA\u03b242 increased the percentage of ROS in neurons\u2010like from 40% to 65%, and the treatment with tubastrine reduced it to 50%. The antioxidant power of neurons\u2010like after oA\u03b242 decreased significantly, while the compound reversed it, reaching similar values to the untreated cells. Therefore, tubastrine can reverse an important pathophysiological mechanism of AD, oxidative stress, by increasing neuronal antioxidant power and reducing ROS levels, able to prevent neuron\u2010like cell death caused by oA\u03b242.<\/jats:p>","DOI":"10.1111\/jcmm.70165","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T17:39:35Z","timestamp":1734716375000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Tubastrine, an antioxidant molecule from <i>Tubastraea tagusensis<\/i> sun coral, in the reversion of oxidative stress and neuron's death induced by A\u03b242"],"prefix":"10.1111","volume":"28","author":[{"given":"Amanda G.","family":"Silva","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Produtos Naturais Universidade S\u00e3o Francisco  Bragan\u00e7a Paulista Brazil"},{"name":"Unidade Integrada de Farmacologia e Gastroenterologia (UNIFAG)  Bragan\u00e7a 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