{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:48:08Z","timestamp":1792842488807,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T00:00:00Z","timestamp":1729987200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Endometritis is mostly caused by childbirth or postpartum uterine infection. It is one of the important reasons leading to female infertility. Caffeic acid (CA) and its derivatives are widely found in some foods and traditional Chinese medicine, and have biological activities such as antioxidant, free radical scavenging, anti\u2010inflammatory, and anti\u2010infection. In this study, we aimed to explore the effect of CA on\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    \u2010induced endometritis. The contents of TNF\u2010\u03b1 and IL\u20101\u03b2 were detected by ELISA in\n                    <jats:italic>S. aureus<\/jats:italic>\n                    \u2010induced endometritis model. Western blot assay was used to detect the expression of AMPK\u03b1\/mTOR\/HIF\u20101\u03b1 pathway related proteins and GPX4 expression. In addition, the concentrations of MDA, GSH, and iron were tested by the assay kits. Compared with the model group, CA treatment significantly alleviated\n                    <jats:italic>S. aureus<\/jats:italic>\n                    \u2010induced uterine injury, MPO activity, the contents of inflammatory factors TNF\u2010\u03b1 and IL\u20101\u03b2, and NF\u2010\u03baB activation. Meanwhile, CA significantly inhibited\n                    <jats:italic>S. aureus<\/jats:italic>\n                    \u2010induced ferroptosis, as confirmed by decreased MDA and iron concentration and up\u2010regulated GPX4 expression and GSH level. Furthermore, CA attenuated\n                    <jats:italic>S. aureus<\/jats:italic>\n                    \u2010induced HIF\u20101\u03b1 and phosphorylated mTOR expression and increased phosphorylated AMPK expression. In conclusion, CA inhibits inflammation and ferroptosis by regulating AMPK\u03b1\/mTOR\/HIF\u20101\u03b1 signalling pathway to alleviate\n                    <jats:italic>S. aureus<\/jats:italic>\n                    \u2010induced endometritis in mice.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.70175","type":"journal-article","created":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T10:29:53Z","timestamp":1730024993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Caffeic acid inhibits\n                    <i>Staphylococcus aureus<\/i>\n                    \u2010induced endometritis through regulating\n                    <scp>AMPK\u03b1<\/scp>\n                    \/\n                    <scp>mTOR<\/scp>\n                    \/\n                    <scp>HIF<\/scp>\n                    \u20101\u03b1 signalling pathway"],"prefix":"10.1111","volume":"28","author":[{"given":"Lu","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Obstetrics China\u2010Japan Union Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology China\u2010Japan Union Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8921-757X","authenticated-orcid":false,"given":"Cong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gynecology China\u2010Japan Union Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology China\u2010Japan Union Hospital of Jilin University Changchun  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