{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:38:29Z","timestamp":1789616309720,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001057"],"award-info":[{"award-number":["82001057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2024112010"],"award-info":[{"award-number":["H2024112010"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Periodontitis is a significant independent risk factor for atherosclerosis. Yet, the exact mechanism of action is still not fully understood. In this study, we investigated the effect of exosomes\u2010miR\u2010155\u20105p derived from periodontal endothelial cells on atherosclerosis in\u00a0vitro and in\u00a0vivo. Higher expression of miR\u2010155\u20105p was detected in the plasma exosomes of patients with chronic periodontitis (CP) and carotid atherosclerosis (CAS) compared to patients with CP. Also, the expression level of miR\u2010155\u20105p was associated with the severity of CP. miR\u2010155\u20105p\u2010enriched exosomes from HUVECs increased the angiogenesis and permeability of HAECs and promoted the expression of angiogenesis, permeability, and inflammation genes. Along with the overexpression or inhibition of miR\u2010155\u20105p, the biological effect of HUVECs\u2010derived exosomes on HAECs changed correspondingly. In ApoE\u2212\/\u2212 mouse models, miR\u2010155\u20105p\u2010enriched exosomes promoted the occurrence of carotid atherosclerosis by increasing permeable and angiogenic activity. Collectively, these findings highlight a molecular mechanism of periodontitis in CAS, uncovering exosomal miR\u2010155\u20105p derived periodontitis affecting carotid endothelial cells in an \u2018exosomecrine\u2019 manner. Exosomal miR\u2010155\u20105p may be used as a biomarker and target for clinical intervention to control this intractable disease in future, and the graphic abstract was shown in Figure\u00a0.<\/jats:p>","DOI":"10.1111\/jcmm.70187","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T13:10:09Z","timestamp":1730725809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Exosomal\n                    <scp>miR<\/scp>\n                    \u2010155\u20105p promote the occurrence of carotid atherosclerosis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4291-4842","authenticated-orcid":false,"given":"Wen\u2010Wen","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Stomatology, Xuanwu Hospital Capital Medical University  Beijing 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