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Geraniin (GE), a polyphenol isolated from an herb called <jats:styled-content style=\"fixed-case\"><jats:italic>Phyllanthus amarus<\/jats:italic><\/jats:styled-content>, possesses anti\u2010angiogenic properties. This study aimed to explore the mechanism of action of GE in CNV. GE was found to activate the angiotensin\u2010converting enzyme 2 (ACE2)\/angiotensin 1\u20137 (Ang\u2010[1\u20137])\/MAS1 proto\u2010oncogene, G protein\u2010coupled receptor (MasR)\/interleukin\u201010 (IL\u201010) pathway in hypoxic human choroidal endothelial cells (HCECs) in\u00a0vitro and mouse models of laser\u2010induced CNV in\u00a0vivo. Activation of the ACE2\/Ang\u2010(1\u20137)\/MasR\/IL\u201010 pathway by GE attenuated the proliferative, migratory, and tube\u2010forming abilities of hypoxic HCECs and prevented the development of CNV in mice. Notably, GE did not cause ocular or systemic toxicity in mice with CNV. These findings suggest that GE alleviates CNV by activating the ACE2\/Ang\u2010(1\u20137)\/MasR\/IL\u201010 pathway in choroidal endothelial cells (CECs).<\/jats:p>","DOI":"10.1111\/jcmm.70228","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T03:44:39Z","timestamp":1733197479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Geraniin Alleviates Mouse Laser\u2010Induced Choroidal Neovascularisation by Inhibiting Choroidal Endothelial Cell <scp>ACE2<\/scp>\/Ang\u2010(1\u20137)\/<scp>MasR<\/scp>\/<scp>IL<\/scp>\u201010 Pathway"],"prefix":"10.1111","volume":"28","author":[{"given":"Hongyi","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Pediatrics Nantong First People's Hospital (The Second Affiliated Hospital of Nantong University)  Nantong Jiangsu 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