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As defined by the World Health Organisation, DCM constitutes a significant cardiac pathology, leading to increased morbidity and mortality due to complications such as heart failure and arrhythmias. The diagnostic process for DCM predominantly employs echocardiography and MRI, with biomarkers like NT\u2010pro BNP and troponin providing supportive, yet non\u2010specific, evidence. Exosomes, small extracellular vesicles, play a critical role in intercellular communications by transferring biomolecules including lipids, proteins, messenger RNA (mRNA) and non\u2010coding RNA (ncRNA) to target cells, thereby influencing key cellular processes such as proliferation, differentiation, apoptosis, angiogenesis and immune modulation. Within the ncRNA category, circular RNAs (circRNAs) are notable for their cellular specificity and evolutionary conservation and are often implicated in the regulatory mechanisms underlying DCM and heart failure. This investigation employed next\u2010generation sequencing technology to analyse plasma exosomal circRNA profiles in DCM patients with chronic heart failure (CHF), compared to healthy controls. The analysis revealed distinct circRNA expression patterns, identifying 49 uniquely expressed circRNAs in the DCM cohort with CHF. These circRNAs were associated with several critical biological pathways, including the sequestration of extracellular ligands from receptors, N\u2010acetyltransferase activity, histone acetyltransferase activity and endocytic vesicle membrane composition. The findings of this study provide valuable insights into the pathophysiological mechanisms of DCM and offer evidence for improving clinical diagnostic methodologies.<\/jats:p>","DOI":"10.1111\/jcmm.70258","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:41:26Z","timestamp":1735087286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Differential Expression Spectrum of\n                    <scp>circRNA<\/scp>\n                    in Plasma Exosomes in Dilated Cardiomyopathy With Heart Failure"],"prefix":"10.1111","volume":"28","author":[{"given":"Shuai","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Henan Province Key Laboratory of Cardiac Injury and Repair  Zhengzhou China"},{"name":"Henan Province Clinical Research Center for Cardiovascular Diseases  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