{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:43:26Z","timestamp":1789872206941,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Endometritis is one of the common reproductive diseases in human and animal. In recent years, a number of studies have found that <jats:italic>Schisandra<\/jats:italic> B (Sch B), as a natural Chinese medicine extract, has antioxidant, anti\u2010inflammatory and other biological activities. Based on the above, in this study, mice were used to conduct an in\u00a0vivo experiment to investigate the effect and mechanism of Sch B on lipopolysaccharide (LPS)\u2010induced endometritis. Haematoxylin and eosin (H&amp;E) staining was used to detect the pathological changes of uterine tissue and western blot was used to detect the expression levels of signalling pathways and key genes for ferroptosis. The results showed that Sch B significantly inhibited the pathological injury of uterine tissue, myeloperoxidase (MPO) activity, the activation of NF\u2010\u03baB pathway and the production of TNF\u2010\u03b1 and IL\u20101\u03b2. Furthermore, Sch B effectively inhibited ferroptosis by inhibiting malondialdehyde (MDA) and iron production and promoting the expression of ferroptosis suppressor genes GPX4 and ferritin. In conclusion, Sch B inhibited LPS\u2010induced endometritis through alleviating inflammatory response and ferroptosis via AMPK\/PGC1\u03b1\/Nrf2 signalling pathway.<\/jats:p>","DOI":"10.1111\/jcmm.70281","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T04:15:00Z","timestamp":1733804100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Schisandrin B Inhibits <scp>LPS<\/scp>\u2010Induced Endometritis Through Attenuating Ferroptosis via <scp>AMPK<\/scp>\/<scp>PGC1\u03b1<\/scp>\/Nrf2 Signalling Pathway"],"prefix":"10.1111","volume":"28","author":[{"given":"Jing","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Endocrinology Affiliated Hospital of Changchun University of Traditional Chinese Medicine  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Affiliated Hospital of Changchun University of Traditional Chinese Medicine  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Affiliated Hospital of Changchun University of Traditional Chinese Medicine  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Affiliated Hospital of Changchun University of Traditional Chinese Medicine  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine 964th Hospital  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshuang","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Affiliated Hospital to Changchun University of Chinese Medicine  Changchun Jilin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2007-2819","authenticated-orcid":false,"given":"Shaohui","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Affiliated Hospital of Changchun University of Traditional Chinese Medicine  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"250","article-title":"Chronic Endometritis: Old Problem, Novel Insights and Future Challenges","volume":"13","author":"Puente E.","year":"2020","journal-title":"International Journal of Fertility & Sterility"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719108330087"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2016.08.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.10.019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2012.02104.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2019.103720"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.03.023"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.12.058"},{"key":"e_1_2_8_10_1","first-page":"4997","article-title":"Pharmacokinetic and Nephroprotective Benefits of Using Extracts in a Cyclosporine A\u2010Based Immune\u2010Suppressive Regime","volume":"9","author":"Lai Q.","year":"2015","journal-title":"Drug Design Development and Therapy"},{"key":"e_1_2_8_11_1","first-page":"2001","article-title":"Schisandrin B Inhibits Cell Growth and Induces Cellular Apoptosis and Autophagy in Mouse Hepatocytes and Macrophages: Implications for Its Hepatotoxicity","volume":"9","author":"Zhang Y.","year":"2015","journal-title":"Drug Design Development and Therapy"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2020.1782079"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2022.155200"},{"key":"e_1_2_8_14_1","first-page":"598","article-title":"Suppression of MAPK and NF\u2010\u03baB Pathways by Schisandrin B Contributes to Attenuation of DSS\u2010Induced Mice Model of Inflammatory Bowel Disease","volume":"70","author":"Li W. 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