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Nonetheless, the precise contribution of this pathway to AAA development remains to be elucidated. The AAA mouse model was induced by local incubation with elastase and oral administration of \u03b2\u2010aminopropionitrile. The activity level of the CXCL12\/CXCR4 axis was evaluated in both human AAA patients and the mouse model. Smooth muscle cell lineage tracing determined the expression and localisation of CXCR4 in normal aorta and AAA tissue. By transfecting the MiR206\u20103p sponge to reduce the level of MiR206\u20103p in AAA, the effects of the CXCL12\/CXCR4 pathway on AAA progression as well as the apoptosis and phenotypic transformation of vascular smooth muscle cells (VSMCs) were studied in\u00a0vivo and in\u00a0vitro. Single\u2010cell RNA sequencing analysis, serum ELISA, and in\u00a0vivo experiments indicate a pronounced activation of the CXCL12\/CXCR4 axis in both AAA patients and the mouse model. Specific blocking of the CXCL12\/CXCR4 axis significantly inhibited further expansion and rupture of the abdominal aorta and reduced the infiltration of inflammatory cells in the aorta and inhibited the phenotypic transformation of contractile VSMCs into a macrophage\u2010like state. Our findings propose that MiR206\u20103p sponge represents an innovative therapeutic strategy to attenuate AAA progression and rupture risk, primarily through the suppression of the CXCL12\/CXCR4 signalling pathway.<\/jats:p>","DOI":"10.1111\/jcmm.70328","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T03:25:58Z","timestamp":1736393158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Inhibition of Abdominal Aortic Aneurysm Progression Through the <scp>CXCL12<\/scp>\/<scp>CXCR4<\/scp> Axis via <scp>MiR206<\/scp>\u20103p Sponge"],"prefix":"10.1111","volume":"29","author":[{"given":"Xuezhen","family":"Xuan","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery The Second Hospital of Shanxi Medical University  Taiyuan 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