{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:28:52Z","timestamp":1781893732032,"version":"3.54.5"},"reference-count":218,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019491","name":"National Natural Science Foundation of China - State Grid Corporation Joint Fund for Smart Grid","doi-asserted-by":"publisher","award":["82274119"],"award-info":[{"award-number":["82274119"]}],"id":[{"id":"10.13039\/501100019491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Osteoporosis, recognised as a metabolic disorder, has emerged as a significant burden on global health. Although available treatments have made considerable advancements, they remain inadequately addressed. In recent years, the role of epigenetic mechanisms in skeletal disorders has garnered substantial attention, particularly concerning m<jats:sup>6<\/jats:sup>A RNA modification. m<jats:sup>6<\/jats:sup>A is the most prevalent dynamic and reversible modification in eukaryotes, mediating various metabolic processes of mRNAs, including splicing, structural conversion, translation, translocation and degradation and serves as a crucial component of epigenetic modification. Research has increasingly validated that m<jats:sup>6<\/jats:sup>A plays a vital role in the proliferation, differentiation, migration, invasion,and repair of bone marrow mesenchymal stem cells (BMSCs), osteoblasts and osteoclasts, all of which impact the whole process of osteoporosis pathogenesis. Continuous efforts have been made to target m<jats:sup>6<\/jats:sup>A regulators and natural products derived from traditional medicine, which exhibit multiple biological activities such as anti\u2010inflammatory and anticancer effects, have emerged as a valuable resources for m<jats:sup>6<\/jats:sup>A drug discovery. This paper elaborates on m<jats:sup>6<\/jats:sup>A methylation and its regulatory role in osteoporosis, emphasising its implications for diagnosis and treatment, thereby providing theoretical references.<\/jats:p>","DOI":"10.1111\/jcmm.70344","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T03:18:27Z","timestamp":1736392707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Epigenetic Mechanisms in Osteoporosis: Exploring the Power of <scp>m<sup>6<\/sup>A RNA<\/scp> Modification"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6038-8076","authenticated-orcid":false,"given":"Shuo","family":"Tian","sequence":"first","affiliation":[{"name":"Academy of Traditional Chinese Medicine Henan University of Chinese Medicine  Zhengzhou China"},{"name":"Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu\u2010Yao  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yagang","family":"Song","sequence":"additional","affiliation":[{"name":"Academy of Traditional Chinese Medicine Henan University of Chinese Medicine  Zhengzhou China"},{"name":"Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu\u2010Yao  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Academy of Traditional Chinese Medicine Henan University of Chinese Medicine  Zhengzhou China"},{"name":"Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu\u2010Yao  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Bai","sequence":"additional","affiliation":[{"name":"Academy of Traditional Chinese Medicine Henan University of Chinese Medicine  Zhengzhou China"},{"name":"Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu\u2010Yao  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingsan","family":"Miao","sequence":"additional","affiliation":[{"name":"Academy of Traditional Chinese Medicine Henan University of Chinese Medicine  Zhengzhou China"},{"name":"Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu\u2010Yao  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2023.2208750"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.244"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.15644\/asc57\/2\/3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2022.10.030"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-023-06818-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528376"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-37944-x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v12.i9.660"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000287"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4640-4"},{"issue":"1","key":"e_1_2_10_12_1","first-page":"Cd004143","article-title":"Long\u2010Term Hormone Therapy for Perimenopausal and Postmenopausal Women","volume":"1","author":"Marjoribanks J.","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030808"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41999-023-00820-y"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.24"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.01.010"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2341"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3230"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.042"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/47412"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2218"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1066726"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.04.025"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1691"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.482"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-021-00721-x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02028-9"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.783322"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101641"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.047"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.041178.113"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3724"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.02.015"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-019-0318-1"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.100"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0057-1"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108174"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10677-0"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14224851"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.11138\/ccmbm\/2017.14.1.209"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202052146"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b02236"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmr.2606"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105387"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2005.187"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmr.2800"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10895-017-2086-2"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01510-2"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/227561a0"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.1029218"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn328"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201805959"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-023-02862-8"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.09.015"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.045"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13146-w"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz559"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12158"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-02227-8"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00315-9"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01159-9"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw482"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01201-w"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr586"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1330"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14281"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.08.005"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.56251"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1099-7"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01746-6"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.774627"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-021-00831-5"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.75466"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201744940"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0270-4"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz619"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.819335"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.05.048"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2022.01.013"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19342"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz1147"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01204-7"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01500-4"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0861-z"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-018-0019-0"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.092"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.687"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1151710"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.10.015"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42271"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1033-z"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12626"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.014"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.15"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31311"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.01.012"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.09.021"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.99"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0045-z"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00872-8"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.011"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14234"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-018-0113-8"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1053-8"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-021-00234-1"},{"issue":"22","key":"e_1_2_10_106_1","first-page":"3936","article-title":"Fragile X Mental Retardation Protein Modulates the Stability of Its m6A\u2010Marked Messenger RNA Targets","volume":"27","author":"Zhang F.","year":"2018","journal-title":"Human Molecular Genetics"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600282"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00366"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020457"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20112784"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-020-00385-4"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368915X689622"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1015"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X10666150531173309"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.11.014"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4300"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.168"},{"issue":"4","key":"e_1_2_10_118_1","first-page":"555","article-title":"Bone and Stem Cells. Regulatory Mechanism of Mesenchymal Stem Cell Differentiation to Osteoblasts","volume":"24","author":"Endo I.","year":"2014","journal-title":"Clinical Calcium"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06898-4"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030551"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2022.2125751"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13234"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-022-03588-y"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.12.001"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3481"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203630"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116433"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211051594"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14526"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20231186"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05362-y"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1093\/stcltm\/szac049"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2023.13053"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203778"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2024.114138"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1093\/stcltm\/szad020"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05627-0"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203377"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00756-8"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.09.015"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2284-8"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04312-4"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13607"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06304-x"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00157-0"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.9.081307.164437"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15284"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010199"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101610R"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110335"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167273"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-01925-4"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111038"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-022-00825-y"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13298"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.12134"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021741"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1122"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00234"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-008-0583-8"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051660"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03915-1"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23829"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2022.116652"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiae021"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2022.109464"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20958"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904032378"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2022.119358"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e18876"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.90485"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.923185"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.01.048"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/boneres.2016.9"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.2929"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmp018"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2425-5"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-024-01628-8"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/42648"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-012-0109-0"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.132159.111"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217708978"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.11.024"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05565-x"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13040470"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00774-2"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06546-y"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03536-w"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202100291"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202000011"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4573-y"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12335"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027312"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja3064149"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1276"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.11.031"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau7116"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c02828"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.990078"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.1072948"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.957742"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-018-0034-6"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-020-01278-3"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.05.168"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5735279"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03021-8"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106937"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01023-y"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202052348"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01359-x"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28551"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-018-0082-5"},{"key":"e_1_2_10_213_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO02004C"},{"key":"e_1_2_10_214_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.55574"},{"key":"e_1_2_10_215_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.62.11.4039-4043.1996"},{"key":"e_1_2_10_216_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.20657"},{"key":"e_1_2_10_217_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S291865"},{"key":"e_1_2_10_218_1","article-title":"Study on the Mechanism of Xianling Gubao Capsule Regulating Runt\u2010Related Transcription Factor 2 (RUNX2) and Promoting Osteoblast Differentiation by N6\u2010Methyladenosine (m6A) Methyltransferase\u2010Like 3 (METTL3)","author":"Liao M.","journal-title":"Alternative Therapies in Health and Medicine"},{"key":"e_1_2_10_219_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202400341"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.70344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:47:49Z","timestamp":1746852469000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.70344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":218,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/jcmm.70344"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.70344","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70344"}}