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Of note, metabolic disorders such as insulin resistance (IR) and type 2 diabetes (T2D) are associated with the development of brain IR and associated neurodegeneration. In addition, AD neuropathology and linked cognitive impairment accelerate the development of peripheral IR and the progression of T2D. Therefore, there is a bidirectional relationship between T2D and AD. It has been demonstrated that AD and T2D induce dysregulation of peroxisome proliferator\u2010activated receptor alpha (PPAR\u2010\u03b1) leading to the central and peripheral metabolic disturbances. Hence, dysregulated PPAR\u2010\u03b1 could be a shared mechanism in both AD and T2D, and restoration of PPAR\u2010\u03b1 signalling by PPAR\u2010\u03b1 agonist fenofibrate (FN) may alleviate T2D and AD. Therefore, this review aims to shed light on the potential involvement of PPAR\u2010\u03b1 in T2D and AD, and how FN could be effective in the management of AD. FN seems to be effective in both AD and T2D by dual neuroprotective and antidiabetic effects that can mitigate AD neuropathology and T2D\u2010related complications by modulating various cellular processes and inflammatory signalling pathways. 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