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To elucidate its molecular function, scratch tests, transwell migration and invasion assays were conducted, with PCR and western blot analyses verifying molecular regulatory relationships. RNA pulldown and RNA immunoprecipitation tests were also employed to investigate underlying mechanisms. Results indicate that RBM6 enhances prostate cell migration by suppressing CDH1, yet ZEB1 overexpression alleviates this suppression. Notably, under these conditions, RBM6's inhibitory effect on MMP16 becomes more pronounced, reducing cell migration ability. Thus, under normal conditions, RBM6 promotes prostate tumour cell migration, but in the context of high ZEB1 expression, it inhibits migration. This shift in RBM6's regulatory capacity towards downstream genes underscores the importance of considering objective conditions in studying RBM6 molecules.<\/jats:p>","DOI":"10.1111\/jcmm.70397","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T03:44:47Z","timestamp":1738640687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Oncopromoting Gene <scp>RBM6<\/scp> Inhibits Prostate Tumour Cell Migration During Epithelial\u2010to\u2010Mesenchymal Transition"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2059-5916","authenticated-orcid":false,"given":"Ruoyang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Key Laboratory of Urinary Tumors Henan Provincial Health Commission  Zhengzhou Henan 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