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Adding cardioprotective molecules may further reduce the damage\u2010triggered ischemia\/reperfusion (I\/R) injury. Angiotensin\u2010(1\u20139) (Ang\u2010(1\u20139)) and angiotensin\u2010(1\u20137) (Ang\u2010(1\u20137)), members of the counter\u2010regulatory renin\u2010angiotensin system, have shown cardioprotective effects in cardiac hypertrophy and I\/R models. This study aimed to evaluate the effects of Ang\u2010(1\u20139) and Ang\u2010(1\u20137), as adjuvants of the DNC, on cardioprotection and ventricular function in isolated rat hearts subjected to I\/R and in cultured neonatal rat ventricular myocytes subjected to simulated I\/R (sI\/R). The addition of DNC and Ang\u2010(1\u20139) and Ang\u2010(1\u20137) decreased lactic dehydrogenase (LDH) release in cultured cardiomyocytes subjected to sI\/R in comparison to those cardiomyocytes subjected to sI\/R and incubated with DNC alone. Moreover, hearts treated with Ang\u2010(1\u20139) during reperfusion after DNC\u2009+\u2009I\/R exhibited fewer arrhythmias and required less time to reach left ventricular developed pressure stability. Overall, reperfusion with DNC and Ang\u2010(1\u20139) improves the recovery of the left ventricular function of the heart.<\/jats:p>","DOI":"10.1111\/jcmm.70412","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T11:53:52Z","timestamp":1739361232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Angiotensin\u2010(1\u20139) Improves the Cardioprotective Effects of Del Nido Cardioplegia Against Ischemia\/Reperfusion Injury"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4586-3753","authenticated-orcid":false,"given":"Evelyn","family":"Mendoza\u2010Torres","sequence":"first","affiliation":[{"name":"Grupo de Investigaci\u00f3n Avanzada en Biomedicina, Faculty of Health, Exact and Natural Sciences Universidad Libre Seccional Barranquilla  Barranquilla Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Programa de Fisiopatolog\u00eda, Instituto de Ciencias Biom\u00e9dicas, Facultad de Medicina Universidad de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Rosales","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Avanzada en Biomedicina, Faculty of Health, Exact and Natural Sciences Universidad Libre Seccional Barranquilla  Barranquilla Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Clara","family":"Ospino","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Avanzada en Biomedicina, Faculty of Health, Exact and Natural Sciences Universidad Libre Seccional Barranquilla  Barranquilla Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1589-2411","authenticated-orcid":false,"given":"Luis Antonio","family":"D\u00edaz\u2010Ariza","sequence":"additional","affiliation":[{"name":"Internal Medicine Program, Faculty of Health Sciences Universidad Libre Seccional Barranquilla  Barranquilla Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuliet","family":"Montoya","sequence":"additional","affiliation":[{"name":"Grupo de Din\u00e1mica Cardiovascular, Centro de Bioingenier\u00eda Universidad Pontificia Bolivariana  Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Bustamante","sequence":"additional","affiliation":[{"name":"Grupo de Din\u00e1mica Cardiovascular, Centro de Bioingenier\u00eda Universidad Pontificia Bolivariana  Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime A.","family":"Riquelme","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacotherapy, Departamento de Qu\u00edmica Farmacol\u00f3gica y Toxicol\u00f3gica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas Universidad de Chile  Santiago Chile"},{"name":"Interuniversity Center for Healthy Aging  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Chiong","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas &amp; Facultad de Medicina Universidad de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4258-1483","authenticated-orcid":false,"given":"Sergio","family":"Lavandero","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas &amp; Facultad de Medicina Universidad de Chile  Santiago Chile"},{"name":"Department of Internal Medicine (Cardiology Division) University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.04.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(55)93381-X"},{"key":"e_1_2_10_4_1","first-page":"71","article-title":"Myocardial Protection: The Rebirth of Potassium\u2010Based Cardioplegia","volume":"26","author":"Shiroishi M. 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