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The proper endocrine environment regulates endometrial functions: menstruation and supporting pregnancy. Obesity is closely related to endometrial dysfunction, which seriously affects women's health and fertility, but the pathological mechanism is unknown. Chemerin is an adipokine involved in multiple biological events such as immunity and metabolism by acting on its functional receptors. This study aimed to characterise the effects of chemerin on human endometrial epithelial cells by RNA\u2010Seq.\u00a012Z cells were utilised as the model because immunoblot results showed that they expressed endometrial markers, epithelial markers and functional receptors for chemerin. Principal component analysis (PCA) showed that chemerin treatment significantly altered the transcriptome. Differential Expression Analysis found 388 significant differentially expressed genes (DEG) in the chemerin treatment group compared with the controls. Gene Set Enrichment Analysis (GSEA) showed that chemerin inhibited lipid metabolism and induced the epithelial\u2010mesenchymal transition (EMT)\u2010like process and cellular senescence. More importantly, GSEA and immunoblots showed that chemerin restrained the STAT3 signalling pathway, which is required for endometrial receptivity establishment. Collectively, these findings provide new evidence that over\u2010produced chemerin underlying the endometrial dysfunctions in obesity.<\/jats:p>","DOI":"10.1111\/jcmm.70417","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T13:04:18Z","timestamp":1742735058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemerin's Role in Endometrial Dysfunction: Insights From Transcriptomic Analysis"],"prefix":"10.1111","volume":"29","author":[{"given":"Ming","family":"Yu","sequence":"first","affiliation":[{"name":"Center for Energy Metabolism and Reproduction, Shenzhen Key Laboratory of Metabolic Health, Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichun","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Energy Metabolism and Reproduction, Shenzhen Key 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