{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:27:12Z","timestamp":1788460032078,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016350","name":"Sichuan Provincial Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2024MS509"],"award-info":[{"award-number":["2024MS509"]}],"id":[{"id":"10.13039\/501100016350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Increasing research has indicated that circular RNAs (circRNAs) are crucial for the development of ulcerative colitis (UC). Thus, we attempted to identify the role of hsa_circ_0004662 in UC progression. Hsa_circ_0004662 expression was determined via qRT\u2010PCR. Lipopolysaccharide (LPS)\u2010induced inflammation in normal colonic epithelial cells (ECs). The hsa_circ_0004662 content was then assessed in a mucosal inflammatory bowel disease (IBD) model. Cell proliferation was examined via CCK\u20108 and EdU uptake assays. Apoptotic rates were analysed via flow cytometry. The protein content was quantified via Western blotting. Enzyme\u2010linked immunosorbent assay kits were used to detect IL\u20101\u03b2, TNF\u2010\u03b1 and IL\u20106, and dual\u2010luciferase reporter (DLR) assays were used to identify interactions between miR\u2010532 and circ_0004662 or HMGB3. An animal model of UC was also developed for confirmation. In this study, we identified the function of hsa_circ_0004662 in promoting UC progression. Hsa_circ_0004662 was upregulated in clinical UC tissues and LPS\u2010induced colonic ECs, and its knockdown inhibited apoptosis, reduced inflammatory cytokine release and promoted cell proliferation in\u00a0vitro. Mechanistically, hsa_circ_0004662 acted as a molecular sponge for miR\u2010532, which targets HMGB3. The hsa_circ_0004662\/miR\u2010532\/HMGB3 axis was further validated in a DSS\u2010induced colitis mouse model, where hsa_circ_0004662 knockdown attenuated inflammation and tissue damage. These findings suggested that hsa_circ_0004662 contributes to UC progression through the miR\u2010532\/HMGB3 signalling pathway, offering potential targets for UC therapy.<\/jats:p>","DOI":"10.1111\/jcmm.70430","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T13:41:36Z","timestamp":1742305296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hsa_circ_0004662 Accelerates the Progression of Ulcerative Colitis via the microRNA\u2010532\/HMGB3 Signalling Axis"],"prefix":"10.1111","volume":"29","author":[{"given":"Chunhua","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Geriatric Gastroenterology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Xia","sequence":"additional","affiliation":[{"name":"Geriatrics Research Institute, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Geriatric Gastroenterology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Gastroenterology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Gastroenterology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5978-5310","authenticated-orcid":false,"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Gastroenterology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2020.07.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.23814"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i22.2963"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.20805.1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/asj.13357"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade5079"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01286-3"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2808173"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.71840"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab188"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929866530666230511115213"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524023666221103161203"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i3.252"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.028"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i40.11236"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.02.069"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.765474"},{"issue":"5","key":"e_1_2_10_20_1","first-page":"805","article-title":"Effects of Circular RNA Circ\u2010SOD2 on Intestinal Epithelial Barrier and Ulcerative Colitis","volume":"51","author":"Wang T. 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