{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:56:17Z","timestamp":1783976177836,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Muse cells, pluripotent stem cells present mainly in the bone marrow (BM) selectively accumulate to damaged tissue by sensing sphingosine\u20101\u2010phosphate (S1P) and replace damaged cells by differentiating in\u00a0situ. Acute myocardial infarction (AMI) model rabbits were subcutaneously injected either with Vehicle (<jats:italic>n<\/jats:italic>\u2009=\u200915), S1PR2\u2010agonist (<jats:italic>n<\/jats:italic>\u2009=\u200916), or S1PR2\u2010agonist + S1PR2\u2010antagonist (<jats:italic>n<\/jats:italic>\u2009=\u200910). The number of Muse cells in the peripheral blood was assessed by flow cytometry at 12\u2009h after AMI. The S1PR2\u2010agonist group showed a significant increase in the peripheral\u2010blood Muse cell number at 12\u2009h (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), as well as infarct size reduction (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and improvement of left ventricular (LV) function (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) at 2\u2009weeks compared with the other 2 groups. The number of peripheral\u2010blood Muse cells positively correlated with LV ejection fraction (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and inversely correlated with infarct size (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Transplanted autologous green fluorescent protein (GFP)\u2010labelled BM\u2010Muse cells into the BM, followed by the administration of either Vehicle (<jats:italic>n<\/jats:italic>\u2009=\u20095) or S1PR2 agonist (<jats:italic>n<\/jats:italic>\u2009=\u20095) revealed a higher number of homed GFP\u2010Muse cells expressing the cardiac markers troponin\u2010I, \u03b1\u2010actinin, connexin\u201043 and the vascular marker CD31 in the border areas in the S1PR2\u2010agonist group compared with the vehicle group. The mobilisation of endogenous Muse cells using S1PR2\u2010agonist may be a promising therapeutic approach.<\/jats:p>","DOI":"10.1111\/jcmm.70447","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T18:02:22Z","timestamp":1744912942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sphingosine\u20101\u2010Phosphate Receptor 2 Agonist Mobilises Endogenous Muse Cells to Repair Damaged Myocardial Tissue in Male Rabbits"],"prefix":"10.1111","volume":"29","author":[{"given":"Shingo","family":"Minatoguchi","sequence":"first","affiliation":[{"name":"Department of Cardiology Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Cardiology Gifu University Graduate School of Medicine  Gifu 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