{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:28:16Z","timestamp":1791624496103,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The incidence of stress\u2010induced gastritis is gradually increasing. Vitamin E (VE) is widely used in inflammatory diseases due to its efficient antioxidant and anti\u2010inflammatory effects. Here, we investigated the protective role of VE on stress\u2010induced gastritis and its potential mechanisms. Mice were subjected to high\u2010intensity stress caused by the forced swim test (FST) and gavaged with VE (300\u2009mg\/kg) at different time points. The results showed that VE significantly alleviated stress\u2010induced gastric mucosal injury and related histopathological changes. Additionally, the expression levels of nuclear factor erythroid 2\u2010related factor 2 (Nrf2), haem oxygenase\u20101 (Hmox1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) were upregulated in the administrated groups, while the nuclear factor kappa B (NF\u2010\u03baB) signalling pathway was inhibited, manifested as the expression level of p\u2010NF\u2010\u03baB p65 protein decreased. Furthermore, VE reduced the infiltration of macrophages in gastric tissue, followed by a synchronous decrease in the expression level of interleukin\u20101 beta (IL\u20101\u03b2) protein. Importantly, the detection of cell death by TUNEL assay and SYTOX green staining demonstrated that VE reduced cell death of gastric tissue and subsequently downregulated the pro\u2010apoptotic factor BCL2\u2010associated X Protein (Bax). Hence, our study suggested that VE has an outstanding preventive and therapeutic effect on stress\u2010induced gastritis via promoting Nrf2 and inhibiting NF\u2010\u03baB signalling.<\/jats:p>","DOI":"10.1111\/jcmm.70463","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T16:40:20Z","timestamp":1748277620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Vitamin E Inhibits Oxidative Stress and Inflammation in Stress\u2010Induced Gastritis via Modulating Nrf2 and NF\u2010\u03baB Signalling Pathways"],"prefix":"10.1111","volume":"29","author":[{"given":"Xiaolin","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College Jiangsu University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department 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