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The niosomes were prepared using the thin film hydration method and exhibited a drug loading efficiency of 52.2%. They demonstrated high monodispersity, with mean sizes lower than 200\u2009nm. The results showed a significant reduction in mean dermal thickness from 1195\u2009\u03bcm before treatment to 750\u2009\u03bcm after the 2\u2010month treatment period. This reduction in dermal thickness and improved skin softness can be attributed to the decomposition of accumulated skin collagen in individuals with scleroderma. Additionally, the treatment was found to be effective in reducing skin collagen levels compared to conventional treatment options that merely impede collagen synthesis. The current study underscores the potential of bromelain niosomal hydrogel as a promising strategy for managing skin fibrosis in scleroderma.<\/jats:p>","DOI":"10.1111\/jcmm.70478","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T08:29:29Z","timestamp":1753345769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Niosomal Hydrogel Loaded With Bromelain: A Promising Solution for Reducing Skin Collagen in Scleroderma Patients"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6309-1593","authenticated-orcid":false,"given":"Hanieh","family":"Ardeshiri","sequence":"first","affiliation":[{"name":"Department of Medical Nanotechnology School of Advanced Medical Sciences and Technologies  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Ghorbani","sequence":"additional","affiliation":[{"name":"Chemical 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