{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:20:24Z","timestamp":1783549224695,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diabetes foot ulcers (DFU) are the most common foot injuries leading to lower extremity amputation. Our study aimed to provide the first representative analysis highlighting the vital role of Tertiary Lymphoid Organs (TLO) inflammatory landscape in diabetic foot ulcers. The study explores mechanisms of TLO formation and the disease\u2010specific roles of TLOs in regulating peripheral inflammatory and immune responses. Additionally, comprehensive analysis of clinical data from DFU cases, focused on TLO pathophysiology and systemic immune\u2010inflammation landscape, is documented, aiming to identify the risk factors contributing to the development of DFUs. Our experimental results showed very significant differences were observed among the IL\u201017 and IFN\u2010\u03b3 cytokine levels between the DFU vs. Control and DFU vs. NIDFU (Non\u2010Infectious Diabetic Foot Ulcers) groups, while minimal differences were observed in IL\u20106 and TNF\u2010\u03b1 cytokine levels. Immunohistochemistry staining or Immunophenotyping of DFU patient\u2010derived wound samples for TLO inflammatory stratification showed remarkable differences between DFU, NIDFU, and control groups both in CD3\n                    <jats:sup>+<\/jats:sup>\n                    T Cells and CD20\n                    <jats:sup>+<\/jats:sup>\n                    B cells. Overall, our study findings highlight the perspective role of TLO in DFU mechanisms and its prudent role in regulating peripheral inflammatory\u2010immune responses. TLO study\u2010related significant findings might be one of the important mechanisms, and its effective unveil might be a valuable treatment modality for DFU\u2010complications.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.70479","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T21:36:49Z","timestamp":1743457009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Uncovering the Role of Tertiary Lymphoid Organs in the Inflammatory Landscape: A Novel Immunophenotype of Diabetic Foot Ulcers"],"prefix":"10.1111","volume":"29","author":[{"given":"Deboshmita","family":"Banerjee","sequence":"first","affiliation":[{"name":"National Institute of Biomedical Genomics  Kalyani West Bengal India"},{"name":"Regional Centre for Biotechnology (RCB)  Faridabad Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouvik","family":"Paul","sequence":"additional","affiliation":[{"name":"National Institute of Biomedical Genomics  Kalyani West Bengal India"},{"name":"Regional Centre for Biotechnology (RCB)  Faridabad Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Selvan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and General Surgery M. 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