{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:14:46Z","timestamp":1789193686910,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800216"],"award-info":[{"award-number":["81800216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2016CFB254"],"award-info":[{"award-number":["2016CFB254"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2023AFB756"],"award-info":[{"award-number":["2023AFB756"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Cardiac remodelling, a pathological process induced by various cardiovascular diseases, remains a significant challenge in clinical practice. Here, we investigate the potential of Danuglipron (PF\u201006882961, PF), a novel oral glucagon\u2010like peptide\u20101 (GLP\u20101) receptor agonist, in alleviating pressure overload (PO)\u2010induced cardiac hypertrophy and fibrosis. Using both in\u00a0vivo and in\u00a0vitro models, we demonstrate that PF treatment (1\u2009mg\/kg\/day, orally for 8\u2009weeks) significantly attenuates aortic banding\u2010induced cardiac dysfunction and pathological remodelling in mice. Mechanistically, we show that PF mitigates apoptotic responses and enhances autophagy by promoting AMPK phosphorylation and increasing HSP70 expression. Notably, the cardioprotective effects of PF are abolished in AMPK\u03b12 knockout mice, with no observable increase in HSP70 levels. Our findings reveal a previously unrecognised role of PF in cardiac protection, mediated through the AMPK\u03b1\u2010HSP70 signalling pathway, and suggest its potential as a therapeutic strategy for PO\u2010induced cardiac remodelling.<\/jats:p>","DOI":"10.1111\/jcmm.70488","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T09:01:56Z","timestamp":1741770116000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Danuglipron Ameliorates Pressure Overload\u2010Induced Cardiac Remodelling Through the <scp>AMPK<\/scp> Pathway"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9040-4670","authenticated-orcid":false,"given":"Pan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University  Wuhan P.R. China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases  Wuhan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zhongnan Hospital of Wuhan University  Wuhan P.R. China"},{"name":"Hubei Provincial Clinical Research Center for Cardiovascular Intervention  Wuhan P.R. China"},{"name":"Institute of Myocardial Injury and Repair Wuhan University  Wuhan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Yan","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University  Wuhan P.R. China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases  Wuhan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Lan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University  Wuhan P.R. China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases  Wuhan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University  Wuhan P.R. China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases  Wuhan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Ru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University  Wuhan P.R. China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases  Wuhan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University  Wuhan P.R. China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases  Wuhan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00605-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/M23\u20103236"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mnc.2002.123207"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25094900"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48970-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.026728"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155710"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000001625"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000077"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202400070R"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-018-6837-3"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.870699"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01856"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.565751"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2024.106010"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.19-443"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2503093"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-024-01360-4"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2024.08.001"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.11.040"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2010.40.7.299"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107691"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00820-3"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-022-00950-2"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201611177"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.23768"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15728"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-024-00817-8"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28227639"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6053727"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1617-y"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-62465-6"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmab099"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-020-07088-5"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173318"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.70488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:27:27Z","timestamp":1743380847000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.70488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/jcmm.70488"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.70488","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70488"}}