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While Kindlin\u20103 has been linked to angiogenesis in breast cancer, its specific function in the context of MI remains largely unexplored. Although Kindlin\u20103 has been implicated in breast cancer\u2010related angiogenesis, its role in MI remains underexplored. This study investigates the role of Kindlin\u20103 in promoting angiogenesis, a process critical for cardiac recovery following MI. The study demonstrated a significant upregulation of Kindlin\u20103 in cardiac microvascular endothelial cells (CMECs) in mice post\u2010MI. Overexpression of Kindlin\u20103, achieved through cardiotropic adeno\u2010associated virus serotype 9 (AAV9) with the endothelial\u2010specific promoter Tie2, enhanced myocardial angiogenesis, improved cardiac function, decreased cardiomyocyte apoptosis and reduced fibrosis. In\u00a0vitro, Kindlin\u20103 overexpression promoted CMECs proliferation, migration, tube formation and the expression of angiogenesis\u2010related genes. Conversely, Kindlin\u20103 knockdown exerted opposite effects. Mechanistically, Kindlin\u20103 activated the Notch signalling pathway, as its effects were abrogated by the Notch inhibitor DAPT and \u03b21 integrin knockdown. This study identifies Kindlin\u20103 as a novel enhancer of angiogenesis and suggests its potential as a therapeutic target for myocardial repair.<\/jats:p>","DOI":"10.1111\/jcmm.70494","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T13:22:35Z","timestamp":1742304155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Kindlin\u20103 Promotes Angiogenesis via Notch Signalling and Is Crucial for Functional Recovery Postmyocardial Infarction"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2914-1726","authenticated-orcid":false,"given":"Yan","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital with Nanjing Medical University  Nanjing Jiangsu 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