{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:46:52Z","timestamp":1787237212879,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chronic degenerative changes in cartilage and subchondral bone that lead to instability of the cartilage microenvironment are essential for the development of osteoarthritis (OA) in the old. Synchronous repair of cartilage and subchondral bone may be a key strategy for OA treatment. PDGF\u2010BB effectively promoted chondrocyte regeneration and angiogenesis. However, the mechanisms by which PDGF\u2010BB affects subchondral bone and the delivery of PDGF\u2010BB to the joint cavity need to be further explored. In this study, we used sodium hyaluronate to deliver PDGF\u2010BB (SH\u2010PDGF) to the joint space and aimed to determine the mechanisms of SH\u2010PDGF in repairing cartilage and subchondral bone and stabilising the cartilage microenvironment. In this research, we determined the pharmacokinetics of PDGF\u2010BB and SH\u2010PDGF in cartilage. Moreover, we investigated the effects of PDGF\u2010BB and SH\u2010PDGF on cartilage and the subchondral bone microenvironment by identifying changes in the HIF\u2010VEGF\u2010Notch axis and SDF\u20101\u2010CXCR4 axis in an OA rat model. The results showed that PDGF\u2010BB increased cell viability, decreased HIF\u20101\u03b1 levels, inhibited inflammation and improved matrix metabolism in osteoarthritic chondrocytes under hyperoxic or hypoxic conditions. We also found that PDGF\u2010BB and SH\u2010PDGF showed similar effects on repairing cartilage and subchondral bone simultaneously. However, SH\u2010PDGF had some advantages over PDGF\u2010BB in prolonging the injection interval and decreasing the injection time. These protective effects were mediated by the inhibition of both the HIF\u20101\u03b1\u2010VEGF\u2010Notch axis and the SDF\u20101\u2010CXCR4 axis. The underlying mechanisms include the inhibition of HIF\u20101\u03b1\u2010VEGF\u2010Notch\u2010mediated vessel invasion and SDF\u20101\u2010CXCR4 axis\u2010mediated crosstalk between cartilage and subchondral tissue.<\/jats:p>","DOI":"10.1111\/jcmm.70515","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T21:41:24Z","timestamp":1743457284000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sodium Hyaluronate\u2010\n                    <scp>PDGF<\/scp>\n                    Repairs Cartilage and Subchondral Bone Microenvironment via\n                    <scp>HIF<\/scp>\n                    \u20101\u03b1\u2010\n                    <scp>VEGF<\/scp>\n                    \u2010Notch and\n                    <scp>SDF<\/scp>\n                    \u20101\u2010\n                    <scp>CXCR4<\/scp>\n                    Inhibition in Osteoarthritis"],"prefix":"10.1111","volume":"29","author":[{"given":"Zhengchao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Sports Medicine Wuhan Fourth Hospital  Wuhan China"},{"name":"Hubei Provincial Sports Medicine Center  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Hubei Provincial Sports Medicine Center  Wuhan China"},{"name":"Department of Cardiovascular Wuhan Fourth Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Li","sequence":"additional","affiliation":[{"name":"Zibo First Hospital, Zibo Prevention and Treatment Hospital for Occupation Diseases  Zibo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Ye","sequence":"additional","affiliation":[{"name":"Hubei Provincial Sports Medicine Center  Wuhan China"},{"name":"Department of Rehabilitation Wuhan Fourth Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Luo","sequence":"additional","affiliation":[{"name":"Hubei Provincial Sports Medicine Center  Wuhan China"},{"name":"Department of Rehabilitation Wuhan Fourth Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangxia","family":"Cheng","sequence":"additional","affiliation":[{"name":"Hubei Provincial Sports Medicine Center  Wuhan China"},{"name":"Department of Anesthesiology Wuhan Fourth Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3967-8727","authenticated-orcid":false,"given":"Yu","family":"Cai","sequence":"additional","affiliation":[{"name":"Hubei Provincial Sports Medicine Center  Wuhan China"},{"name":"Department of Rehabilitation Wuhan Fourth Hospital  Wuhan 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