{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:48:29Z","timestamp":1794271709147,"version":"4.9.0"},"reference-count":69,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174140"],"award-info":[{"award-number":["82174140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174401"],"award-info":[{"award-number":["82174401"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ23H270003"],"award-info":[{"award-number":["LQ23H270003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by chronic inflammation and immune dysregulation, significantly impacting multiple organ systems, including the joints. While SLE is known to contribute to musculoskeletal complications, its role in hip arthritis development and the underlying mechanisms remain poorly understood. This study aims to investigate the relationship between SLE and hip arthritis progression using MRL\/\n                    <jats:italic>lpr<\/jats:italic>\n                    mice, which exhibit early\u2010onset SLE, compared with MRL\/\n                    <jats:italic>MpJ<\/jats:italic>\n                    control mice at 14\u2009weeks of age. Through comprehensive histological, immunohistochemical and molecular analyses, we evaluated articular cartilage (AC) degeneration, extracellular matrix (ECM) metabolism, inflammatory responses, and chondrocyte pyroptosis. Our results demonstrated that MRL\/\n                    <jats:italic>lpr<\/jats:italic>\n                    mice developed an accelerated hip arthritis\u2010like phenotype, manifesting as enhanced AC degeneration, impaired chondrocyte proliferation, heightened apoptosis and promoted inflammatory cytokine production. Notably, SLE markedly stimulated chondrocyte pyroptosis by increasing pyroptosis\u2010related proteins, including NLRP3, ASC, CASPASE\u20101 and GSDMD, via activating the NF\u2010\u03baB pathway. These findings establish a novel mechanistic link between SLE and hip arthritis progression, demonstrating that SLE promotes chondrocyte pyroptosis to exacerbate AC degeneration via NF\u2010\u03baB activation, highlighting chondrocyte pyroptosis as a key driver of SLE\u2010associated hip arthritis and a potential therapeutic target for mitigating SLE\u2010induced joint manifestations.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.70531","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:55:11Z","timestamp":1743814511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Systemic Lupus Erythematosus Exacerbates Hip Arthritis by Promoting Chondrocyte Pyroptosis in the Femoral Head via Activating the NF\u2010\u03baB Pathway"],"prefix":"10.1111","volume":"29","author":[{"given":"Xuliang","family":"Fang","sequence":"first","affiliation":[{"name":"Institute of Orthopaedics and Traumatology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Traumatology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Traumatology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuchao","family":"Shen","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Traumatology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaobai","family":"Lao","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Traumatology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Traumatology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishan","family":"Bian","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Traumatology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Traumatology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8795-0874","authenticated-orcid":false,"given":"Hongting","family":"Jin","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Traumatology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijian","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqun","family":"Huang","sequence":"additional","affiliation":[{"name":"Hangzhou Fuyang Hospital of TCM Orthopedics and Traumatology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hangzhou Fuyang Hospital of TCM Orthopedics and Traumatology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanbing","family":"Zeng","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangda","family":"Fu","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Traumatology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengliang","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Traumatology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbiao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Taizhou Municipal Hospital  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8868-9313","authenticated-orcid":false,"given":"Hongfeng","family":"Ruan","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Traumatology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.03.002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.39"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102861"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02698-x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/OARRR.S362833"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214819"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203318776093"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2017.07.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.05.018"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2023.153659"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8209"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109136"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-022-02890-y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154663"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01250"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101284"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S486297"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2019.1127"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.71086"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110542"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.912933"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-00848-2"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-01167-2"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100851RR"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102741"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/boneres.2016.44"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.020"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.04.008"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.152958"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.09.017"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.5301\/jn.5000272"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-022-01755-5"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/356314a0"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90375-1"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930410001666622"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.72351"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2014.08.007"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.196"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113447"},{"key":"e_1_2_9_41_1","volume-title":"Systemic Lupus Erythematosus","author":"Gordon C.","year":"2016"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313502109"},{"issue":"4","key":"e_1_2_9_43_1","first-page":"187","article-title":"Delay in the Diagnosis of SLE: The Importance of Arthritis\/Arthralgia as the Initial Symptom","volume":"57","author":"Ozbek S.","year":"2003","journal-title":"Acta Medica Okayama"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309345795"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-016-0608-6"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/lds038"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22171"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.5.1198"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1150661"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.200.Supp.40.2"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-74-6-911"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.46497\/ArchRheumatol.2020.7514"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14501"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308089990"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2004.04.006"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.114376"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74786-3"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-00998-3"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112261"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.720877"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155556"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.621300"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S382675"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1462777"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113589"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114118"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114216"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S417598"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205373"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1004142"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.70531","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.70531","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.70531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:22:37Z","timestamp":1772983357000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.70531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":69,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/jcmm.70531"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.70531","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2025-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70531"}}