{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:35:52Z","timestamp":1767094552905,"version":"3.48.0"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>MicroRNAs (miRNAs) are short non\u2010coding RNAs essential for biological functions that control the process of translation of mRNA into protein. The discovery of miRNAs in mesenchymal stem cells (MSCs), especially in odontogenic tissues and dental follicles, has not been fully characterised. This study focused on characterising dental follicle stem cells (DFSCs) in terms of their ability to proliferate and differentiate into osteoblasts using qRT\u2010PCR (miR\u2010203, miR\u2010125 and miR\u201021) and immunohistochemistry (OCT4 and CD133). Dental follicles are essential for tooth eruption as they envelop the enamel organ and dental papilla and control the development and breakdown of the alveolar bone. Dental follicle progenitor cells (DFPCs) are stem cells located in dental follicles that differentiate into several cell types that are essential for tooth development and eruption. We observed that miR\u2010125 was upregulated in fibromyxoid and myxoid tissues during odonto\/osteogenic differentiation of hDFPCs (fold change values, respectively, 1.75\u2009\u00b1\u20090.98 and 2.17\u2009\u00b1\u20091.03). miR\u2010203 and miR\u201021 significantly downregulated odonto\/osteogenic differentiation in myxoid, fibromyxoid and fibroid tissues (fold change values, respectively: miR\u2010203: 0.57\u2009\u00b1\u20090.25, 0.38\u2009\u00b1\u20090.11, 0.21\u2009\u00b1\u20090.18; miR\u201021: 0.21\u2009\u00b1\u20090.14, 0.21\u2009\u00b1\u20090.13, 0.082\u2009\u00b1\u20090.14). Ultimately, utilising miRNA signatures in humans as a predictive tool will help us understand the molecular processes involved in DFSCs.<\/jats:p>","DOI":"10.1111\/jcmm.70541","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T01:04:15Z","timestamp":1745888655000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epigenetic Regulation of Dental Follicle Stem Cells in Odontogenic Regeneration"],"prefix":"10.1111","volume":"29","author":[{"given":"Sibel Elif","family":"Gultekin","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Dental Faculty Gazi University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4133-0319","authenticated-orcid":false,"given":"Leyla","family":"Arslan Bozdag","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Dental Faculty Gazi University  Ankara Turkey"},{"name":"Department of Biology, Faculty of Science Gazi University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarete","family":"Odenthal","sequence":"additional","affiliation":[{"name":"Institute for Pathology, Medical Faculty and University Hospital of Cologne University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Peter","family":"Dienes","sequence":"additional","affiliation":[{"name":"Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0499-86"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.150.5.1085"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100714.1980.tb00377.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.2007.00245.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700801"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90597-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/344435a0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2795(200004)55:4<452::AID-MRD14>3.0.CO;2-S"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.19-4-271"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/74199"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0611"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.12.5013"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.12.5002"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.01.050"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2001.020202.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017590"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0639"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030236"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2019.11.004"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-019-00358-7"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12736"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1508520112"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-021-10054-x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes8010004"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.01.073"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X17666220617103820"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16720-8"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00227-2"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0625"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2008.01.014"},{"key":"e_1_2_10_32_1","first-page":"62","article-title":"Colorectal Cancer Stem Cells: Relation to Clinico\u2010Pathological Features and Prognosis","volume":"12","author":"Shamaa S.","year":"2016","journal-title":"Journal of American Science"},{"key":"e_1_2_10_33_1","first-page":"517","article-title":"Oct\u20104 Is Associated With Gastric Cancer Progression and Prognosis","volume":"9","author":"Jiang W. 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