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A systematic review and meta\u2010analysis was conducted with the primary objective of investigating the roles of MCP\u20101 in the gingival crevicular fluid (GCF) of subjects with chronic periodontitis compared to periodontally healthy subjects. The study protocol adhered to PRISMA guidelines. Digital searches were carried out across several databases, including PubMed, Dentistry &amp; Oral Science Source, ScienceDirect, Scopus, Web of Science and Google Scholar. The quality of the studies was evaluated using the JBI tool for cross\u2010sectional studies and clinical trials. To assess the concentration of MCP\u20101 in the GCF of the exposure group versus the control group, a meta\u2010analysis was conducted employing a random\u2010effects model. The search strategy yielded 1694 articles, with 14 studies meeting the inclusion criteria and 10 articles subjected to quantitative analysis. A total of 497 subjects were examined, comprising 298 cases and 199 controls. The meta\u2010analysis indicated a significant increase in MCP\u20101 levels in the GCF of individuals with chronic periodontitis compared to healthy subjects (GCF: SMD\u2009=\u200920.29, 95% CI: 10.33\u201330.25,\n                    <jats:italic>Z<\/jats:italic>\n                    \u2009=\u20093.992,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001*). GCF MCP\u20101 levels are elevated in periodontitis compared to healthy controls, suggesting its potential future use as a diagnostic tool in clinical settings.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.70545","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T23:36:17Z","timestamp":1746747377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Relationship Between\n                    <scp>MCP<\/scp>\n                    \u20101 Levels in\n                    <scp>GCF<\/scp>\n                    and Periodontitis: A Systematic Review With Meta\u2010Analysis and Analysis of Molecular Interactions"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6727-7969","authenticated-orcid":false,"given":"Mario Alberto","family":"Alarc\u00f3n\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Molecular Biology Department, University 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