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Further research is needed to elucidate the molecular mechanisms underlying senile osteoporosis. This study found that FKBP5 expression in bone marrow mesenchymal stem cells (BMSCs) increases with age and is inversely correlated with patients' bone mineral density and CT values. Functional analyses revealed that FKBP5 plays a crucial regulatory role in BMSC osteogenic differentiation, acting through the canonical WNT\/\u03b2\u2010catenin signalling pathway. FKBP5 binds to \u03b2\u2010catenin, promoting its ubiquitination and degradation. Importantly, administration of SAFit2, a selective FKBP5 inhibitor, enhanced bone mineral density in an animal model of senile osteoporosis. These findings suggest that FKBP5 may represent a novel therapeutic target and provide new insights into the treatment of senile osteoporosis.<\/jats:p>","DOI":"10.1111\/jcmm.70552","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T04:11:32Z","timestamp":1745208692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["FKBP5 Induces Senescence in BMSCs and Inhibits Osteogenic Differentiation Through the Canonical WNT\/\u03b2\u2010Catenin Signalling Pathway in Senile Osteoporosis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3161-6938","authenticated-orcid":false,"given":"Bin","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital with Nanjing Medical University  Nanjing Jiangsu 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