{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:10:31Z","timestamp":1787015431616,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cardiomyopathy encompasses a diverse range of conditions characterised by extensive molecular heterogeneity, particularly the variations in cell\u2013cell communication events such as ligand\u2010receptor interactions and downstream signalling. Understanding the common and unique features of these intercellular interactions is crucial for advancing targeted treatments. We analysed single\u2010cell RNA sequencing datasets from the ventricular regions of patients with arrhythmogenic cardiomyopathy (ACM), dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM) and healthy donors (HD), as well as ischemic cardiomyopathy (ICM). Our analyses focused on cell type\u2010specific disease preferences, differential gene expression, pathway enrichment and particularly cell\u2013cell communication. We observed that inflammatory, autoimmune, angiogenesis, lymphangiogenesis and fibrotic extracellular matrix deposition are consistently enriched across all four disease subtypes, highlighting their universal significance in disease progression through intercellular interactions. Additionally, we identified subtype\u2010specific pathways that reflect distinct intercellular communication patterns unique to each disease subtype: arrhythmia\u2010associated pathways in ACM, chronic inflammation\u2010related pathways in DCM, ECM remodelling pathways in HCM and ischaemic injury and recovery pathways in ICM.<\/jats:p>","DOI":"10.1111\/jcmm.70554","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T23:38:58Z","timestamp":1746747538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characterising Shared and Specific Cell\u2013Cell Communication in Cardiomyopathy Subtypes From Single\u2010Cell Transcriptomics Data"],"prefix":"10.1111","volume":"29","author":[{"given":"Wenqi","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Cardiology, Jing'an District Centre Hospital of Shanghai Fudan University  Shanghai 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