{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:04:10Z","timestamp":1788447850242,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The present study investigates the effects of cannabidiol (CBD), the major non\u2010psychoactive compound of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Cannabis sativa<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. extracts, on ferroptotic cell death in human articular chondrocytes. Exposure to known ferroptosis inducers RSL3, erastin and its analogue IKE, FINO2 and FIN56 led to a varying extent of reduced cell viability in two chondrocyte cell lines (in C\u201028\/I2, T\/C\u201028\/A2) and primary chondrocytes, suggesting different sensitivity and defence mechanisms towards the respective substances. The cytotoxic effects were aggravated by additional exposure to iron and inhibited by the specific ferroptosis inhibitor ferrostatin\u20101 (Fer\u20101), proving the occurrence of ferroptosis. Strikingly, co\u2010treatment of ferroptosis inducers with CBD clearly restored cell viability in a dose\u2010dependent manner (10\u2009nM to 1\u2009\u03bcM CBD) in both cell lines and primary chondrocytes. Moreover, CBD restored the activity of GPX4, a major anti\u2010oxidative enzyme, to varying degrees when combined with IKE or RSL3. Increasing evidence has emerged for an important role of iron dyshomeostasis and ferroptosis in the onset and progression of various orthopaedic diseases, including osteoarthritis. Therefore, the here demonstrated and previously unreported cytoprotective and anti\u2010oxidative effects of CBD in the context of ferroptosis have highly promising therapeutic implications.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.70592","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T08:13:59Z","timestamp":1751012039000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cannabidiol Is a Potential Inhibitor of Ferroptosis in Human Articular Chondrocytes"],"prefix":"10.1111","volume":"29","author":[{"given":"A.","family":"Wipplinger","sequence":"first","affiliation":[{"name":"Center of Physiology, Pathophysiology and Biophysics, Institute of Physiology and Pathophysiology Paracelsus Medical University  Salzburg Austria"},{"name":"Ludwig Boltzmann Institute for Arthritis and Rehabilitation  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bekric","sequence":"additional","affiliation":[{"name":"Center of Physiology, Pathophysiology and Biophysics, Institute of Physiology and Pathophysiology Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ablinger","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kittl","sequence":"additional","affiliation":[{"name":"Center of Physiology, Pathophysiology and Biophysics, Institute of Physiology and Pathophysiology Paracelsus Medical University  Salzburg Austria"},{"name":"Ludwig Boltzmann Institute for Arthritis and Rehabilitation  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Mayr","sequence":"additional","affiliation":[{"name":"Center of Physiology, Pathophysiology and Biophysics, Institute of Physiology and Pathophysiology Paracelsus Medical University  Salzburg Austria"},{"name":"Department of Internal Medicine I Paracelsus Medical University\/Salzburger Landeskliniken (SALK)  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ritter","sequence":"additional","affiliation":[{"name":"Center of Physiology, Pathophysiology and Biophysics, Institute of Physiology and Pathophysiology Paracelsus Medical University  Salzburg Austria"},{"name":"Ludwig Boltzmann Institute for Arthritis and Rehabilitation  Salzburg Austria"},{"name":"Gastein Research Institute Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Winklmayr","sequence":"additional","affiliation":[{"name":"Center of Physiology, Pathophysiology and Biophysics, Institute of Physiology and Pathophysiology Paracelsus Medical University  Salzburg Austria"},{"name":"Ludwig Boltzmann Institute for Arthritis and Rehabilitation  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2110-5090","authenticated-orcid":false,"given":"M.","family":"Jakab","sequence":"additional","affiliation":[{"name":"Center of Physiology, Pathophysiology and Biophysics, Institute of Physiology and Pathophysiology Paracelsus Medical University  Salzburg Austria"},{"name":"Ludwig Boltzmann Institute for Arthritis and Rehabilitation  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.03.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u201003118\u20100"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.10.086"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.021"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.158"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2008.02.010"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935\u2010021\u201002366\u20100"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010022\u201001297\u20107"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2023.04.005"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073612"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413\u2010023\u201000247\u2010y"},{"key":"e_1_2_10_14_1","first-page":"37","article-title":"Osteoarthritis Pathogenesis \u2013 A Complex Process That Involves the Entire Joint","volume":"7","author":"Man G. 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