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We synthesised a multifunctional nanoparticle, ZnO@CuEA, and characterised its morphology using transmission electron microscopy. Cytotoxicity was analysed via CCK8 assays and calcein\u2010AM staining. The tumour\u2010targeting capability of ZnO@CuEA was validated using confocal microscopy and in\u00a0vivo imaging experiments. RNA\u2010seq and proteomic analysis were conducted to assess changes in mRNA and protein expression before and after ZnO@CuEA treatment. Lysosomal \u03b2\u2010galactosidase staining was employed for cellular senescence detection, and protein expression levels were analysed via Western blot. Finally, in\u00a0vivo experiments demonstrated the tumour\u2010inhibitory effect of ZnO@CuEA. ZnO@CuEA is a multifunctional nanoparticle capable of targeting tumour cells and inducing cuproptosis. In\u00a0vivo experiments showed that ZnO@CuEA exhibits significant antitumor activity. The multifunctional nanoparticles synthesised in this study provide a novel therapeutic approach for cancer treatment.<\/jats:p>","DOI":"10.1111\/jcmm.70636","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T09:55:21Z","timestamp":1748858121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Targeted ZnO@CuEA Nanoplatform for Cuproptosis\u2010Based Synergistic Cancer Therapy"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2460-3933","authenticated-orcid":false,"given":"Hao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, Xiang'an Hospital of Xiamen University, School of Medicine Xiamen University  Xiamen 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