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P\u2010Coumaric acid (PCA) is a phenolic acid with anti\u2010inflammatory and antioxidant pharmacological actions. This research aims to investigate the effect of PCA on CKD\u2010induced muscle atrophy and its underlying mechanism. In our study, in\u00a0vivo and in\u00a0vitro models were established by using 5\/6 nephrectomized rats and LPS\u2010induced C2C12 myoblasts. The experimental results showed that PCA ameliorated kidney injury in CKD rats and increased skeletal muscle weight and the cross\u2010sectional area of muscle fibres. In both CKD rats and LPS\u2010induced C2C12 myoblasts, PCA also exhibited anti\u2010inflammatory and antioxidant effects, reduced the levels of pro\u2010inflammatory cytokines and enhanced the activity of antioxidant enzymes. Network pharmacology studies have identified 165 common targets between PCA and skeletal muscle atrophy. Furthermore, the experimental results also demonstrated that PCA decreased the expression of TLR4, MyD88, NF\u2010\u03baB p65, MurF1 and MAFbx at both the protein and mRNA levels. Additionally, in\u00a0vitro experiments showed that the use of TLR4 agonists could reverse the muscle\u2010protective effect of PCA. In summary, this study illustrated that PCA ameliorated skeletal muscle atrophy in CKD rats by inhibiting the TLR4\/MyD88\/NF\u2010\u03baB pathway.<\/jats:p>","DOI":"10.1111\/jcmm.70659","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T12:24:57Z","timestamp":1752755097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["P\u2010Coumaric Acid Improves Skeletal Muscle Atrophy in Chronic Kidney Disease by Modulating <scp>TLR4<\/scp>\/<scp>MyD88<\/scp>\/<scp>NF<\/scp>\u2010<scp>\u03baB<\/scp>\u2010Mediated Inflammation and Oxidative Stress"],"prefix":"10.1111","volume":"29","author":[{"given":"Hao","family":"Wang","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine Southern Medical University  Guangzhou Guangdong 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