{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:46:10Z","timestamp":1757609170068,"version":"3.44.0"},"reference-count":37,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005297","name":"Uniwersytet Medyczny w Bialymstoku","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Prostate cancer is the most frequently diagnosed cancer in men and the second most common cause of death. PSA is performed in men to detect prostate cancer early, but PSA levels increase in both cancer and BPH. Therefore, there is an important need to understand prostate\u2010specific molecular signatures. Considering the importance of the MAPK and Wnt\/\u03b2\u2010catenin pathways in the progression of many cancers and the fact that the miRNA expression profile is unique in each cancer type, evaluation of 106a\u20105p and 375\u20103p miRNAs may be an important factor in cancer detection. The research was carried out on tissue fragments taken from 30 patients with BPH and 30 with cancer. IHC and qRT\u2010PCR were used to identify the expression of tested proteins, while the expression of miRNAs was examined using dPCR. The results of the present study showed significantly higher fluorescence intensity of miRNAs 106a\u20105p and 375\u20103p, and lower immunoreactivity and the expression of genes encoding ERK1\/2, p38, \u03b2\u2010catenin and E\u2010cadherin in prostate cancer compared to BPH. It is possible that thanks to miRNA 106a\u20105p and 375\u20103p, the proteins we studied belonging to the MAPK and Wnt\/\u03b2\u2010catenin pathways play a protective suppressor role in prostate cancer cells.<\/jats:p>","DOI":"10.1111\/jcmm.70695","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:38:53Z","timestamp":1755794333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Analysis of <scp>miRNA<\/scp> Expression 106a\u20105p and 375\u20103p and Proteins <scp>ERK1<\/scp>\/2, p38, \u03b2\u2010Catenin and E\u2010Cadherin in Prostate Cancer and Benign Prostatic Hyperplasia"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3398-366X","authenticated-orcid":false,"given":"Magdalena","family":"Smerecza\u0144ska","sequence":"first","affiliation":[{"name":"Department of Histology and Cytophysiology Medical University of Bialystok  Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Domian","sequence":"additional","affiliation":[{"name":"Department of Histology and Cytophysiology Medical University of Bialystok  Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"M\u0142ynarczyk","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Bialystok  Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2954-942X","authenticated-orcid":false,"given":"Irena","family":"Kasacka","sequence":"additional","affiliation":[{"name":"Department of Histology and Cytophysiology Medical University of Bialystok  Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"issue":"2","key":"e_1_2_12_2_1","first-page":"1499","article-title":"miR\u2010202 Suppresses Prostate Cancer Growth and Metastasis by Targeting PIK3CA","volume":"16","author":"Zhang S.","year":"2018","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.554078"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.22.9575"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.5152\/tud.2014.94547"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S119027"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.2225110"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-014-0999-7"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.2414110"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804549105"},{"issue":"4","key":"e_1_2_12_11_1","first-page":"4323","article-title":"MicroRNA\u2010211 Suppresses Prostate Cancer Proliferation by Targeting SPARC","volume":"15","author":"Hao P.","year":"2018","journal-title":"Oncology Letters"},{"issue":"1","key":"e_1_2_12_12_1","first-page":"793","article-title":"MicroRNA\u2010139\u20105P Inhibits Human Prostate Cancer Cell Proliferation by Targeting Notch1","volume":"16","author":"Sun Q.","year":"2018","journal-title":"Oncology Letters"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2010.05.006"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29041"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.5015"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15114"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2014.91"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32498"},{"issue":"5","key":"e_1_2_12_19_1","first-page":"4481","article-title":"Up\u2010Regulation of microRNA\u2010302a Inhibited the Proliferation and Invasion of Colorectal Cancer Cells by Regulation of the MAPK and PI3K\/Akt Signaling Pathways","volume":"8","author":"Wei Z. 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