{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:11:43Z","timestamp":1791227503625,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T00:00:00Z","timestamp":1753574400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["14DZ2260200"],"award-info":[{"award-number":["14DZ2260200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170695"],"award-info":[{"award-number":["82170695"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Inflammatory responses play a critical role in cisplatin\u2010induced acute kidney injury (AKI). Farnesoid X receptor (FXR) has been shown to mitigate kidney dysfunction, but its mechanism remains unclear. This study aims to explore whether FXR reduces cisplatin\u2010induced AKI by modulating inflammation. Using a mouse model of AKI, we demonstrated that cisplatin\u2010induced obvious inflammation in the kidney, evidenced by increased macrophage and neutrophil infiltration, elevated expression of pro\u2010inflammatory cytokines, including interleukin\u20101 beta (IL\u20101\u03b2), IL\u20106, C\u2010X\u2010C motif chemokine ligand (CXCL) 1, 2, 5, 20, and C\u2010C motif chemokine ligand (CCL) 2, and activation of the toll\u2010like receptor 4 (Tlr4)\/nuclear factor\u2010kappa B (NF\u2010\u03baB) pathway. RNA sequencing further corroborated these findings, revealing upregulation of inflammation\u2010related genes and activation of several inflammatory pathways in the kidney after cisplatin administration. Pretreatment with GW4064 (a FXR agonist) reduced inflammatory cytokine expression, immune cell infiltration, and Tlr4\/NF\u2010\u03baB activation, alleviating kidney injury. However, proximal tubule\u2010specific FXR knockout worsened renal inflammation and increased NF\u2010\u03baB activity. In\u00a0vitro, GW4064 decreased pro\u2010inflammatory cytokine production, suppressed Tlr4\/NF\u2010\u03baB signalling, and reduced apoptosis in cisplatin\u2010treated renal tubular epithelial cells. Together, these findings demonstrate that FXR significantly alleviates cisplatin\u2010induced renal inflammation via suppressing Tlr4\/NF\u2010\u03baB signalling. FXR activation may represent a promising therapeutic strategy to mitigate cisplatin\u2010induced AKI.<\/jats:p>","DOI":"10.1111\/jcmm.70730","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T04:10:01Z","timestamp":1753675801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Farnesoid X Receptor Alleviates Cisplatin\u2010Induced Kidney Inflammatory Injury by Inhibiting Tlr4\/<scp>NF<\/scp>\u2010<scp>\u03baB<\/scp> Pathway"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2619-0293","authenticated-orcid":false,"given":"Fangyuan","family":"Peng","sequence":"first","affiliation":[{"name":"Division of Nephrology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghan","family":"Feng","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Zhongshan Hospital 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