{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:32:31Z","timestamp":1786559551934,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100024514","name":"Stem Cell Research Center, Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["71981"],"award-info":[{"award-number":["71981"]}],"id":[{"id":"10.13039\/501100024514","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The contemporary lifestyle has resulted in an epidemic of chronic sleep restriction (SR), which has emerged as a substantial contributor to mood disorders, particularly anxiety and depression. This study examined the effectiveness of AdipoRon (Adipo), a synthetic adiponectin agonist, in mitigating anxious behaviours and depression\u2010like symptoms in a chronic SR mice model. Forty male Swiss albino mice were divided into four groups: wide platform (WP), SR, SR\u2009+\u2009melatonin (Mel), and SR\u2009+\u2009Adipo. Over 21\u2009days, the animals underwent a modified multiple\u2010platform technique to induce SR, followed by daily intranasal treatments. The open field test and elevated plus maze were conducted to assess anxiety\u2010related behaviours, while the forced swimming test and sucrose splash test were used to assess depressive symptoms. Serum corticosterone concentrations, a marker of microglia activation, and pro\u2010inflammatory mediators (NF\u2010\u043aB and IL\u20101\u03b2) in the prefrontal cortex (PFC) were also examined. Intranasal administration of Adipo markedly decreased anxiety\u2010like behaviours, despair, and apathy in sleep\u2010restricted mice compared to the SR group. Adipo therapy also reduced pro\u2010inflammatory proteins and ionised calcium\u2010binding adaptor molecule\u20101 (Iba\u20101)\u2010positive cells in the PFC and restored serum corticosterone levels. These outcomes emphasise the therapeutic benefit of Adipo as an alternative therapy for mood disorders associated with SR.<\/jats:p>","DOI":"10.1111\/jcmm.70770","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T03:45:07Z","timestamp":1754451907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>AdipoRon<\/scp>\n                    Mitigates Anxiety and Depression Symptoms in Chronic Sleep\u2010Restricted Mice via Modulation of Neuroinflammatory Responses"],"prefix":"10.1111","volume":"29","author":[{"given":"Beriwan","family":"Malaei","sequence":"first","affiliation":[{"name":"Neurosciences Research Center Tabriz University of Medical Sciences  Tabriz 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