{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:50:29Z","timestamp":1790286629531,"version":"4.1.0"},"reference-count":88,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Osteoporosis is a systemic skeletal disease characterized by reduced bone mineral density (BMD) and increased fracture risk; it poses a significant global health challenge. The multifactorial pathogenesis of osteoporosis involves complex interactions between genetic factors and vitamin D metabolism, particularly involving key genes such as the vitamin D receptor (VDR), CYP27B1 and CYP24A1. Polymorphisms in these genes, including FokI, BsmI, TaqI and ApaI in the VDR gene, have been associated with variations in BMD, fracture susceptibility and differential responses to vitamin D supplementation, underscoring the importance of personalized medicine. Genome\u2010wide association studies (GWAS) have identified over 500 loci, including WNT16, ESR1 and SOST, linked to osteoporosis\u2010related traits, underlining the disease's polygenic nature and the impact of gene\u2013environment interactions, including dietary vitamin D intake, sun exposure and gene variations. Despite these advancements, translating genetic insights into clinical practice remains challenging, especially due to the variability in genetic determinants and limited access to genotype assessment such as gene sequencing. This review advocates for precision medicine approaches to osteoporosis management. By addressing the gaps in the studies on osteoporosis aetiology, integrating genetic screening into routine diagnosis and care and promoting collaborative efforts in genomics, nutrition and public health, the global burden of osteoporosis can be significantly reduced. This approach offers a promising pathway to improve patient outcomes and advance personalized medicine strategies for osteoporosis as a debilitating condition.<\/jats:p>","DOI":"10.1111\/jcmm.70780","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T04:21:02Z","timestamp":1755663662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genetics and Vitamin D Interactions in Osteoporosis: A Path to Precision Medicine"],"prefix":"10.1111","volume":"29","author":[{"given":"Sepideh","family":"Abdollahi","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, School of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forough","family":"Taheri","sequence":"additional","affiliation":[{"name":"Metabolic Disorders Research Centre, Endocrinology and Metabolism Molecular\u2010Cellular Sciences Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein Sangi Nasab","family":"Lahijan","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, School of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba Hatefi","family":"Shoga","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Basic Sciences Shahrekord University  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Didehban","sequence":"additional","affiliation":[{"name":"Human Genetics Research Center Baqiyatallah University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeid","family":"Doaei","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences, Tehran  Tehran Iran"},{"name":"Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat Barcelona, Spain.  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27071"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.10.006"},{"key":"e_1_2_15_4_1","first-page":"154","article-title":"Economic Burden of Osteoporosis in the World: A Systematic Review","volume":"34","author":"Kemmak A. R.","year":"2020","journal-title":"Medical Journal of the Islamic Republic of Iran"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1514-0"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S138000"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2023.5333"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.18.2257"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.3185"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2016.697"},{"issue":"1","key":"e_1_2_15_11_1","first-page":"1","article-title":"Retracted Article: Associations Between VDR Gene Polymorphisms and Osteoporosis Risk and Bone Mineral Density in Postmenopausal Women: A Systematic Review and Meta\u2010Analysis","volume":"8","author":"Zhang L.","year":"2018","journal-title":"Scientific Reports"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2006.04.009"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092608"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-809965-0.00005-7"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2013.12.016"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10349"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.04.008"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2004.03.023"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2021.105857"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-012-9660-z"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae290"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14194148"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.11.003"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-020-0558-y"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12239"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.23.6.702.32182"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0138"},{"key":"e_1_2_15_28_1","volume-title":"Global Prevalence and Disease Burden of Vitamin D Deficiency: A Roadmap for Action in Low\u2010 and Middle\u2010Income Countries","author":"Roth D. E.","year":"2018"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-019-00559-4"},{"issue":"243","key":"e_1_2_15_30_1","first-page":"65","article-title":"Vitamin D and Bone Health","volume":"72","author":"Turner A. G.","year":"2012","journal-title":"Scandinavian Journal of Clinical and Laboratory Investigation"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2005.12.031"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2011.05.002"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200724120-00005"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.11.002"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu093"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12018-010-9073-3"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.04.005"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-014-9852-9"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00337"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2006.08.001"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-021-00143-3"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k3225"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30558"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.11.8.9951"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules200712389"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14142847"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-013-0147-y"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18670-7"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2020.1787457"},{"issue":"3","key":"e_1_2_15_50_1","first-page":"190","article-title":"The Relationship Between Vitamin D Receptor (VDR) Polymorphism and the Occurrence of Osteoporosis in Menopausal Iranian Women","volume":"13","author":"Dabirnia R.","year":"2016","journal-title":"Clinical Cases in Mineral and Bone Metabolism"},{"issue":"4","key":"e_1_2_15_51_1","first-page":"22","article-title":"Genetic Influence of Vitamin D Receptor Gene Polymorphisms on Osteoporosis Risk","volume":"14","author":"Banjabi A. A.","year":"2020","journal-title":"International Journal of Health Sciences"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014460.2019.1659851"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-20-0296"},{"key":"e_1_2_15_54_1","first-page":"137","article-title":"Vitamin D and Gene Networks in Human Osteoblasts","volume":"5","author":"Peppel J.","year":"2014","journal-title":"Frontiers in Physiology"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.09.016"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23392"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24020"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.03.018"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-019-01163-9"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-019-00500-6"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-006-0691-2"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-007-9024-2"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-003-0168-4"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502230"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-2072-3"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13030837"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200223666220627104139"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2003308"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3884"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11122853"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12081176"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.040133"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43042-020-00057-5"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-022-10197-5"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-022-01218-y"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.558598"},{"issue":"6","key":"e_1_2_15_77_1","first-page":"535","article-title":"Genetic Variations of Vitamin D Receptor and Vitamin D Supplementation Interaction in Relation to Serum Vitamin D and Metabolic Traits: A Systematic Review and Meta\u2010Analysis","volume":"93","author":"Ghiasvand R.","year":"2023","journal-title":"International Journal for Vitamin and Nutrition Research"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41043-021-00272-9"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuaa132"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.992986"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14020360"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.07.074"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.53388\/CRC2023018"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-022-03208-3"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13968"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-23-513"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac147"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2022.103887"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-021-01042-0"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.70780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T08:59:50Z","timestamp":1756889990000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.70780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":88,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/jcmm.70780"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.70780","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70780"}}