{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:03:26Z","timestamp":1792325006975,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZSM202111007"],"award-info":[{"award-number":["SZSM202111007"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Bladder cancer (BC) is one of the 10 most common cancers in the world, and its recurrence and metastasis are the main causes of death in BC patients. Exploring the molecular mechanisms of BC pathogenesis and searching for new prognostic markers and therapeutic targets are important for improving patient prognosis. KPNA2 was found to be a potential oncogene in different malignant tumours, as demonstrated in our previous study. To better understand the mechanisms associated with BC development, we investigated the inhibitory effect of miR\u201020a\u20105p on the oncogene KPNA2. RNA\u2010seq data from BC patients were downloaded through the TCGA database for bioinformatics analysis, including gene expression, co\u2010expression analysis, GSEA, nomogram modelling, functional enrichment analysis, WGCNA, GO and KEGG to assess the potential biological functions of miR\u201020a\u20105p in BC. Subsequently, we further verified the expression of miR\u201020a\u20105p in BC cells by RT\u2010qPCR, and in\u00a0vitro experiments were performed to investigate the effects of this gene on BC cell proliferation and migration. MiR\u201020a\u20105p was downregulated in BC tissues and cells. Kaplan\u2013Meier analysis revealed that the higher the expression of miR\u201020a\u20105p in patients, the higher the survival rate of BC patients. MiR\u201020a\u20105p overexpression inhibited the proliferation and migration of BC cells. In addition, miR\u201020a\u20105p can directly bind to nuclear transporter protein \u03b12 (KPNA2) in cells, targeting and regulating the expression of KPNA2. These findings indicate that miR\u201020a\u20105p targeting KPNA2 adversely affects the proliferation and migration of BC cells, suggesting that miR\u201020a\u20105p may be an attractive target in BC therapy.<\/jats:p>","DOI":"10.1111\/jcmm.70785","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T03:31:46Z","timestamp":1755660706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>MiR<\/scp>\u201020a\u20105p Inhibits Bladder Cancer Proliferation and Migration by Targeting <scp>KPNA2<\/scp>"],"prefix":"10.1111","volume":"29","author":[{"given":"Shuai","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital  Shenzhen China"},{"name":"Shenzhen University Health Science Center  Shenzhen 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