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Natural compounds have emerged as promising alternatives due to their potent anti\u2010cancer properties and reduced side effects. Tamarixetin is an O\u2010methylated flavonol derived from <jats:styled-content style=\"fixed-case\"><jats:italic>Azadirachta indica<\/jats:italic><\/jats:styled-content>, but its potential and clinical utility to suppress CRC progression remain unknown. To figure out the underlying mechanism, the inhibitory effects of Tamarixetin on CRC were evaluated by in\u00a0vitro assays; the validation of Tamarixetin\u2010mediated tumour suppression was performed with CRC xenografts and patient\u2010derived organoids. Our results demonstrated that\u00a0Tamarixetin significantly reduced the proliferation of CRC cells (HT\u201029 and HCT\u2010116) in a dose\u2010dependent manner, with minimal effects on normal colonic epithelial cells (NCM460). Furthermore,\u00a0Tamarixetin inhibited proliferation, migration, and invasion of CRC cells, leading to reduced xenograft tumour growth and sensitising CRC to Oxaliplatin. Mechanistically,\u00a0The expression and protein levels of DPP7 in CRC cells were suppressed by Tamarixetin, which lead to the downregulation of WNT3A\/\u03b2\u2010catenin signalling pathway. This study highlights Tamarixetin as a promising natural compound for CRC treatment by interfering with DPP7\u2010mediated WNT3A\/\u03b2\u2010catenin signalling pathway. These findings provide a novel therapeutic strategy to improve outcomes of CRC.<\/jats:p>","DOI":"10.1111\/jcmm.70787","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T18:09:29Z","timestamp":1755886169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tamarixetin Suppresses Colorectal Cancer Progression by Targeting <scp>DPP7<\/scp>\u2010Mediated <scp>WNT3A<\/scp>\/\u03b2\u2010Catenin Signalling Pathway"],"prefix":"10.1111","volume":"29","author":[{"given":"Peng","family":"Ouyang","sequence":"first","affiliation":[{"name":"Department of General Surgery The First Affiliated Hospital of Jinan University  Guangzhou Guangdong China"},{"name":"Department of Hepatobiliary Surgery First Affiliated Hospital of Gannan Medical University  Ganzhou Jiangxi 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