{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T09:09:52Z","timestamp":1764666592393,"version":"3.46.0"},"reference-count":38,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Confined migration (CM) is a key step in the process of cancer cell metastasis. However, the molecular mechanisms underlying CM in gastric cancer (GC) remain unclear. Here, we found that CM\u2010GC cells had remarkable metastatic and antiapoptotic capacities. Moreover, we observed that HIF\u20101\u03b1 was highly expressed in CM\u2010GC cells. HIF\u20101\u03b1 knockdown reversed the enhanced metastatic and antiapoptotic capacities of CM\u2010GC cells in\u00a0vitro and in\u00a0vivo. Mechanistically, HIF\u20101\u03b1 enhanced the metastatic and antiapoptotic capacities of CM\u2010GC cells through phosphatidylcholine (PC) synthesis. Importantly, the addition of L\u2010\u03b1\u2010phosphatidylcholine (L\u2010\u03b1\u2010PC), a natural PC, markedly increased the metastatic and antiapoptotic capacities of GC cells, similar to CM GC cells. In addition, we observed that increased HIF\u20101\u03b1 protein expression was positively correlated with the expression of CEPT1, a key enzyme of PC synthesis, in GC tissue samples. Furthermore, high expression of HIF\u20101\u03b1 and CEPT1 in GC tissues predicted poor prognosis in patients with GC. Overall, our study supports the crucial role of HIF\u20101\u03b1 in the CM of GC cells and provides novel therapeutic targets and strategies for metastatic GC.<\/jats:p>","DOI":"10.1111\/jcmm.70828","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:21:12Z","timestamp":1757996472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HIF\u20101\u03b1 Promotes the Confined Migration of Gastric Cancer Cells by Modulating Phosphatidylcholine Metabolism"],"prefix":"10.1111","volume":"29","author":[{"given":"Ming","family":"Zhou","sequence":"first","affiliation":[{"name":"Jiangsu Institute of Clinical Immunology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Jiangsu Key Laboratory of Clinical Immunology Soochow University  Suzhou China"},{"name":"Department of Gastroenterology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanger","family":"Shen","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Clinical Immunology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Jiangsu Key Laboratory of Clinical Immunology Soochow University  Suzhou China"},{"name":"Department of Gastroenterology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyi","family":"Huang","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Clinical Immunology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Department of Gastroenterology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Clinical Immunology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Jiangsu Key Laboratory of Clinical Immunology Soochow University  Suzhou China"},{"name":"Department of Gastroenterology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhe","family":"Mao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Clinical Immunology Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5382-2775","authenticated-orcid":false,"given":"Tongguo","family":"Shi","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Clinical Immunology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Clinical Immunology Soochow University  Suzhou China"},{"name":"Department of Gastroenterology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101404"},{"key":"e_1_2_9_4_1","article-title":"Gastric Cancer: A Comprehensive Literature Review","volume":"16","author":"Mithany R. 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