{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T11:03:36Z","timestamp":1779707016202,"version":"3.53.1"},"reference-count":25,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To characterise T\u2010cell immunity and inflammatory profiles in HIV patients with mycobacterial co\u2010infections. This study enrolled 41 HIV patients co\u2010infected with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    <\/jats:styled-content>\n                    (HIV\u2010TB,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200927) or non\u2010tuberculous mycobacteria (HIV\u2010NTM,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200914), along with 30 controls (20 HIV\u2010monoinfected, 10 post\u2010treatment) from a single centre. Flow cytometry quantified T\u2010cell subsets (CD3\u2009+\u2009CD4+, CD3\u2009+\u2009CD8+, CD28+ subsets), mitochondrial parameters (mass [MM], low membrane potential [MMP\u2010low%]) and cytokines (IFN\u2010\u03b3, IL\u20102\/4\/6\/10\/17A, TNF\u2010\u03b1). Co\u2010infected groups showed reduced T\u2010cell counts versus HIV\u2010monoinfected controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Elevated MMP\u2010low% in CD3\u2009+\u2009CD4+\/CD28+ T cells indicated mitochondrial dysfunction in co\u2010infected patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). HIV\u2010TB patients exhibited higher CD3\u2009+\u2009CD4+\/CD28+\/CD8+ T\u2010cell MM than HIV\u2010NTM (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), while HIV\u2010NTM demonstrated greater MMP\u2010low% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Proinflammatory cytokines (IFN\u2010\u03b3, IL\u20106, IL\u201017A) inversely correlated with CD4+ counts and MM, but positively with CD8\u2009+\u2009CD28+ MMP\u2010low%. MMP\u2010low% in CD3\u2009+\u2009CD4\u2009+\u2009CD28+ T cells and IL\u20102 differentiated IRIS\/non\u2010IRIS cases (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), with combined AUC\u2009=\u20090.834 for IRIS prediction (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). HIV\/mycobacterial co\u2010infection exacerbates T\u2010cell depletion and mitochondrial dysfunction, with HIV\u2010NTM showing more severe impairment. MMP\u2010low% and IL\u20102 may serve as biomarkers for IRIS risk stratification.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.70832","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T08:46:48Z","timestamp":1757666808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered T Lymphocytes Mitochondrial Function and Inflammatory Factors of Peripheral Blood in\n                    <scp>HIV<\/scp>\n                    Patients With Mycobacterial Infection"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8813-2555","authenticated-orcid":false,"given":"Mengyan","family":"Wang","sequence":"first","affiliation":[{"name":"Department II of Infectious Diseases, Xixi Hospital of Hangzhou Hangzhou Xixi Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine  Hangzhou 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