{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:18:32Z","timestamp":1787750312643,"version":"build-2784847793"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["119S224"],"award-info":[{"award-number":["119S224"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study assessed the anticancer activity of boron\u2010containing and structurally diverse small molecules in 4T1 breast cancer and Caco\u20102 colon adenocarcinoma cells. Initial screening showed that five boronic acids lacked significant cytotoxicity, underscoring the structural specificity required for boron\u2010mediated bioactivity. Similarly, reference compounds, including fumaric acid, caffeic acid, ferulic acid, dimethyl malonate and N\u2010(tert\u2010butoxycarbonyl)\u2010L\u2010alanine, showed no cytotoxic effect under identical conditions. Among the tested agents, 1\u2010acetyl\u20104\u2010(4\u2010hydroxyphenyl)piperazine (1A4HP) displayed the most potent cytotoxicity, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 149.7\u2009\u03bcM in 4T1 and 825\u2009\u03bcM in Caco\u20102 cells. For comparison, the clinically investigated antimetastatic agent tasquinimod showed moderate activity in 4T1 cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u2009180.7\u2009\u03bcM), serving as a pharmacological benchmark. Mechanistic assays revealed that 1A4HP induced apoptosis and significantly impaired 4T1 cell migration, suggesting combined antiproliferative and antimetastatic effects. Computational analyses further supported 1A4HP's drug\u2010like potential by predicting favourable physicochemical properties, including balanced lipophilicity and high solubility. Molecular docking studies indicated a strong binding affinity to oestrogen receptor alpha (ER\u03b1), surpassing that of tamoxifen. Notably, despite 4T1's ER\u2010negative status, 1A4HP suppressed cell growth, suggesting possible ER\u2010independent or off\u2010target mechanisms, similar to tamoxifen's secondary effects. Collectively, these results identify 1A4HP as a promising lead compound for further exploration in breast cancers.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.70890","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T05:34:14Z","timestamp":1767418454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Investigation of Cytotoxic Effects of Structurally Diverse Small Molecules and In Silico Analysis of 1\u2010Acetyl\u20104\u2010(4\u2010Hydroxyphenyl)piperazine"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0678-0701","authenticated-orcid":false,"given":"Azmi","family":"Yerlikaya","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine Kutahya Health Sciences University  Kutahya Turkey"},{"name":"Department of Medical Genetics, Faculty of Medicine Kutahya Health Sciences University  Kutahya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2198-9386","authenticated-orcid":false,"given":"Emrah","family":"T\u00fcmer","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine Kutahya Health Sciences University  Kutahya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1423-0435","authenticated-orcid":false,"given":"Mustafa","family":"G\u00fczel","sequence":"additional","affiliation":[{"name":"Research Institute for Health Sciences and Technologies (SABITA), Center of Drug Discovery and Development \u0130stanbul Medipol University  Istanbul Turkiye"},{"name":"Department of Basic Pharmaceutical Sciences School of Pharmacy, \u0130stanbul Medipol University  Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195175448.001.0001","volume-title":"Cancer Biology","author":"Ruddon R. 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