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These vesicles, which encompass a variety of subtypes such as exosomes, microvesicles and apoptotic bodies, carry functional proteins, mRNAs, miRNAs and other molecular cargo that influence various physiological processes. In particular, skeletal muscle\u2010derived EVs have recently emerged as a novel category of myokines, contributing to muscle homeostasis through paracrine signalling and exerting systemic endocrine effects on metabolic tissues, including the pancreas, adipose tissue and liver. This review systematically examines the regulatory mechanisms of skeletal muscle\u2010derived EVs, with particular focus on exosomes, in mediating inter\u2010organ crosstalk. 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