{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:35:30Z","timestamp":1791858930961,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aims to explore the association between plasma human terminal complement complex C5b\u20109 (sC5b\u20109) levels and the occurrence of haematopoietic stem cell transplantation\u2010associated thrombotic microangiopathy (TA\u2010TMA) in children. The study retrospectively analysed the data of 131 patients who underwent allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT) at the Department of Haematology\u2010Oncology between May 2020 and July 2023. The clinical data included dynamic data on plasma sC5b\u20109 concentrations and analysed the potential of pre\u2010 and post\u2010transplantation levels for the prediction and diagnosis of TA\u2010TMA after allo\u2010HSCT. The median age of the cohort was 5.9 [3.4, 10.8] years, and it comprised 73 (55.8%) male and 58 (44.2%) female patients. The primary diseases were haematologic malignancy in 57 cases (43.5%), aplastic anaemia in 39 cases (29.8%) and Mediterranean anaemia in 13 cases (9.9%). Out of the 131 patients, 21 (14.7%) developed TA\u2010TMA, and the median time of onset was 88 [59, 136] days after transplantation. The 1\u2010year overall survival rate was significantly higher in the non\u2010TA\u2010TMA group (92.7%\u2009\u00b1\u20092.5%) than in the TA\u2010TMA group (47.6%\u2009\u00b1\u200910.7%) (\u03c7\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200935.71,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). During TA\u2010TMA, sC5\u20109 levels are significantly elevated (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). However, the baseline levels of sC5b\u20109 before allo\u2010HSCT were not related to the development of TA\u2010TMA after the procedure. The plasma sC5b\u20109 concentration after allo\u2010HSCT in children is closely related to the occurrence of TA\u2010TMA, and 306.4\u2009ng\/mL is an optimal clinical cut\u2010off level above which TA\u2010TMA is indicated. This cut\u2010off level was associated with a sensitivity of 90.5% and a specificity of 86.6%. Nonetheless, the diagnosis of TA\u2010TMA should be established in conjunction with clinical manifestations and corroborated by additional laboratory test results.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.70906","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:03:36Z","timestamp":1761123816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the Value of\n                    <scp>sC5b<\/scp>\n                    \u20109 in the Diagnosis of Haematopoietic Stem Cell Transplant\u2010Associated Thrombotic Microangiopathy in Children"],"prefix":"10.1111","volume":"29","author":[{"given":"Linlin","family":"Luo","sequence":"first","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1932-9282","authenticated-orcid":false,"given":"Hao","family":"Xiong","sequence":"additional","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Tao","sequence":"additional","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Du","sequence":"additional","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"sun","sequence":"additional","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Qi","sequence":"additional","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1312353"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.11.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16457"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25922"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-564997"},{"issue":"4","key":"e_1_2_11_7_1","first-page":"S57","article-title":"Reeling in Complement in Transplant\u2010Associated Thrombotic Microangiopathy: You're Going to Need a Bigger Boat","volume":"98","author":"Jodele S.","year":"2023","journal-title":"American Journal of Hematology"},{"issue":"3","key":"e_1_2_11_8_1","first-page":"177","article-title":"Chinese Consensus on the Diagnosis and Management of Transplant\u2010Associated Thrombotic Microangiopathy","volume":"42","author":"Group, H.S.C.A. and Chinese Medical Association, 2021","year":"2021","journal-title":"Zhonghua Xue Ye Xue Za Zhi = Zhonghua xueyexue zazhi"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022526"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.06.001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01283-0"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.01.009"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.569291"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3092-9"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.04.019"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.08.022"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.10.002"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.70906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:55:09Z","timestamp":1761659709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.70906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":16,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/jcmm.70906"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.70906","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70906"}}