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Symptoms include bloody diarrhoea and abdominal pain, which have a significant impact on quality of life. Current treatments mainly alleviate symptoms and maintain remission, but natural therapeutic alternatives are still needed. To investigate the therapeutic effect of pectic polysaccharides from the peel of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Passiflora edulis<\/jats:italic>\n                    <\/jats:styled-content>\n                    on DSS\u2010induced ulcerative colitis in mice, focusing on colonic histoarchitecture, collagen remodelling, MUC\u20102 expression and immune cell distribution. Mice were assigned to a control group, a group with DSS\u2010induced colitis, or a group with HPE treatment (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. edulis<\/jats:italic>\n                    <\/jats:styled-content>\n                    homogalacturonan, 100\u2009mg\/kg). Histomorphometric, histopathologic, and immunohistochemical analyses of the colonic wall, evaluation of collagen remodelling and MUC\u20102 expression, quantification of immune cells and in silico tests were performed. DSS caused atrophy of the muscular and submucosal layers, hypertrophy of the mucosa, increased crypt depth and decreased enterocyte height. HPE improved muscular and submucosal thickness, partially restored enterocyte height, reduced crypt depth and collagen deposition and increased intraepithelial lymphocytes. DSS significantly decreased MUC\u20102 expression in goblet cells, while HPE significantly restored it. Pharmacokinetic and toxicological predictions indicated a favourable safety profile for HPE, and molecular docking analyses suggested interactions with proteins involved in maintaining the integrity of the intestinal barrier. HPE effectively attenuated DSS\u2010induced colon damage and restored MUC\u20102 expression, contributing to epithelial barrier restoration and supporting its therapeutic potential in ulcerative colitis.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.70910","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T14:41:39Z","timestamp":1761835299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Homogalacturonan From Yellow Passion Fruit Peel Ameliorates Intestinal Injury in\n                    <scp>DSS<\/scp>\n                    \u2010Induced Colitis in Mice"],"prefix":"10.1111","volume":"29","author":[{"given":"Samilla Santos Souza","family":"Mazeti","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Bioci\u00eancias e Sa\u00fade Faculdade de Ci\u00eancias da Sa\u00fade da Universidade Federal de Rondon\u00f3polis  Rondon\u00f3polis 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