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However, its therapeutic potential against cardiac hypertrophy remains uncertain. This study aims to investigate the protective effects of TQ on stress\u2010induced cardiac hypertrophy and elucidate the underlying mechanisms. Our findings reveal that TQ mitigates stress\u2010induced cardiac hypertrophy in mice and AngII\u2010induced hypertrophy in H9c2 cells. Moreover, TQ inhibits cardiomyocyte ferroptosis and apoptosis by downregulating PTGS2, Bax, and upregulating GPX4, Bcl\u20102, thereby alleviating cardiac hypertrophy and dysfunction. Mechanistically, the protective effects of TQ against ferroptosis and apoptosis in cardiac hypertrophy were reversed by the PPAR\u2010\u03b3 inhibitor (GW9662). In addition, TQ treatment led to increased protein expression levels of P\u2010PI3K and P\u2010AKt. Taken together, our findings suggest that TQ could attenuate cardiac hypertrophy through activation of the PPAR\u2010\u03b3\/PI3K\/Akt signalling pathway.<\/jats:p>","DOI":"10.1111\/jcmm.70911","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T10:57:40Z","timestamp":1769770660000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thymoquinone Protects Against Cardiac Hypertrophy via\n                    <scp>PPAR<\/scp>\n                    \u2010\u03b3\/\n                    <scp>PI3K<\/scp>\n                    \/Akt Pathway"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5067-8889","authenticated-orcid":false,"given":"Rong\u2010bin","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery The First Affiliated Hospital of Nanchang University  Nanchang China"},{"name":"Institute of Cardiovascular Surgical 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