{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:26:43Z","timestamp":1768516003651,"version":"3.49.0"},"reference-count":100,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2022CFB148"],"award-info":[{"award-number":["2022CFB148"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The angiopoietins (Angs)\u2013Tie\u20102 axis initiates signalling pathways that modulate vascular stability and angiogenesis and plays an important role in a variety of physiological and pathological processes, including inflammation, wound healing and cancer, by regulating endothelial cell proliferation, survival, migration, invasion and\/or differentiation. Disruption of Ang\u20101\/2 and the Tie\u20102 receptor can lead to endothelial cell activation or dysfunction, which can contribute to the pathogenesis of sepsis. Although the mechanisms by which the Ang\u2013Tie\u20102 axis participates in sepsis pathogenesis have not been fully elucidated due to the dynamic and complicated nature of sepsis, Ang\u2013Tie\u20102 axis malfunction causes endothelial cell activation and contributes to sepsis pathogenesis. During the initiation and development of sepsis, endothelial cells secrete Ang\u20102, which inhibits Tie\u20102 activation and subsequent signalling, leading to endothelial damage, increased vascular permeability, exacerbated inflammation and multiorgan injury. In this review, we summarise the latest advances in basic and clinical research on relevant papers from the PubMed database. We aim to offer a comprehensive overview of the current state of the art of the Ang\u2013Tie\u20102 axis in the context of sepsis and to explore the potential therapeutic targets for treating sepsis. A better understanding of the regulatory mechanisms related to the Ang\u2013Tie\u20102 axis could help identify potential therapeutic targets for treating sepsis.<\/jats:p>","DOI":"10.1111\/jcmm.70912","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T08:59:43Z","timestamp":1761123583000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of Tie\u20102 Axis in Sepsis: A Potential Therapeutic Target"],"prefix":"10.1111","volume":"29","author":[{"given":"Jun","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 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