{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T03:44:20Z","timestamp":1781754260657,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Gastric cancer (GC) is a lethal malignancy characterised by poor prognosis. In this study, we identify cytochrome c oxidase subunit 5A (COX5A) as a key metabolic driver and prognostic biomarker in GC.\n                    <jats:italic>COX5A<\/jats:italic>\n                    was upregulated in tumours and correlated with poor survival. Mechanistically,\n                    <jats:italic>COX5A<\/jats:italic>\n                    enhanced mitochondrial oxidative phosphorylation to elevate ATP production, activating PI3K\/Akt signalling to drive proliferation, migration, and invasion. These effects were reversed by PI3K\/Akt inhibitors. JC\u20101 assays revealed\n                    <jats:italic>COX5A<\/jats:italic>\n                    \u2010mediated mitochondrial membrane potential elevation, indicating amplified bioenergetic output. In\u00a0vivo,\n                    <jats:italic>COX5A<\/jats:italic>\n                    silencing suppressed xenograft tumour growth. Our results demonstrate\n                    <jats:italic>COX5A<\/jats:italic>\n                    orchestrates metabolic reprogramming and PI3K\/Akt\u2010mediated progression in GC, positioning it as both a prognostic indicator and therapeutic target.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.70922","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T03:00:52Z","timestamp":1762225252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cytochrome c Oxidase Subunit 5A (COX5A) Enhances Gastric Cancer Progression by Augmenting\n                    <scp>ATP<\/scp>\n                    Synthesis and Activating the\n                    <scp>PI3K<\/scp>\n                    \/Akt Pathway"],"prefix":"10.1111","volume":"29","author":[{"given":"Dongyan","family":"Li","sequence":"first","affiliation":[{"name":"Human Resources Department First Affiliated Hospital of Jinzhou Medical University  Jinzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0944-9988","authenticated-orcid":false,"given":"Limin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases First Affiliated Hospital of Jinzhou Medical University  Jinzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21657"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31288-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-022-02507-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05026-x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-023-00691-z"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01887-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-24-0067"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155761"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103426"},{"key":"e_1_2_10_11_1","article-title":"The Role of Cytochrome c Oxidase in Cellular Bioenergetics and Energy Homeostasis","volume":"8","author":"Moraes C. 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