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This study focuses on elucidating the multi\u2010target and multi\u2010pathway mechanisms through which morusin mitigates aortic dissection progression, integrating network pharmacology, single\u2010cell transcriptomics and experimental validation. Multi\u2010database analysis identified 281 morusin targets and 1741\u2009\n                    <jats:sc>ad<\/jats:sc>\n                    \u2010related genes, with 84 overlaps. Enrichment analyses highlighted IL\u201017, HIF\u20101 and MAPK signalling pathways as potential regulatory hubs. Protein\u2013protein interaction network analysis identified seven key targets, all showing high binding affinity to morusin in molecular docking. Single\u2010cell transcriptomics revealed cell\u2010type\u2010specific dysregulation, notably MAPK8 upregulation in fibroblasts and immune cells. In\u00a0vitro, morusin dose\u2010dependently inhibited AngII\u2010induced vascular smooth muscle cell proliferation and modulated IL\u201017 pathway gene expression. In\u00a0vivo, morusin attenuated aortic dilation and reduced morbidity and mortality in a BAPN\u2010induced AD mouse model. These findings suggest that morusin mitigates AD progression by targeting key inflammatory and apoptotic pathways, supporting its potential as a multi\u2010target therapeutic candidate.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.70971","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T07:58:41Z","timestamp":1767427121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Network Pharmacology, Single\u2010Cell Transcriptomics Unveil the Mechanistic Role of Morusin in Aortic Dissection"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6974-0511","authenticated-orcid":false,"given":"Zhaomeng","family":"Wang","sequence":"first","affiliation":[{"name":"Beijing Tiantan Hospital China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, the Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoran","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second School of Clinical Medicine Southern Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanxiong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Nanping First Hospital Fujian Medical University  Nanping Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukun","family":"Xiang","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, the Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Fu","sequence":"additional","affiliation":[{"name":"The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center Peking University  Beijing China"},{"name":"Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders The Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zixun","family":"Wang","sequence":"additional","affiliation":[{"name":"The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center Peking University  Beijing China"},{"name":"Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders The Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiqing","family":"Jiao","sequence":"additional","affiliation":[{"name":"School of Stomatology Henan University  Kaifeng Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fujian Provincial Hospital  Fuzhou Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenguang","family":"Niu","sequence":"additional","affiliation":[{"name":"School of Stomatology Henan University  Kaifeng Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Engineering Research Center of Medical Devices for Cardiovascular Diseases Ministry of Education, National Clinical Research Center for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4473-6936","authenticated-orcid":false,"given":"Lemin","family":"Zheng","sequence":"additional","affiliation":[{"name":"The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center Peking University  Beijing China"},{"name":"Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders The Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0140-6736(22)01970-5","article-title":"Acute Aortic Dissection","volume":"401","author":"Carrel T.","year":"2023","journal-title":"Lancet"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.36922\/gtm.v1i2.85","article-title":"Effect of Leptin on Aortic Dissection","volume":"1","author":"Chen 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