{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T10:03:30Z","timestamp":1767866610840,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigated the potential causal relationship between gut microbiota (GM) and sleep apnoea using Mendelian randomisation (MR) analysis. Summary\u2010level genome\u2010wide association (GWAS) data for 473 GM and sleep apnoea were obtained from the IEU Open GWAS database. A two\u2010sample MR framework was applied to assess the potential causal effects of GM on sleep apnoea. The primary analysis was conducted using the inverse variance\u2013weighted (IVW) method, complemented by MR\u2010Egger regression, weighted median, weighted mode and simple mode approaches to ensure robustness. To further account for horizontal pleiotropy and weak instrument bias, Bayesian Weighted Mendelian Randomisation (BWMR) analysis was performed as a key sensitivity model. Sensitivity analyses, including heterogeneity tests and pleiotropy assessments, were conducted to evaluate the stability and reliability of the results. IVW identified 33 GM associated with sleep apnoea (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05); BWMR confirmed 24 with significant causal effects, including 10 showing negative (protective) and 14 showing positive (risk) associations. Sensitivity analyses supported robustness: MR\u2010PRESSO indicated outlier signals in 3 GM, Cochran's\n                    <jats:italic>Q<\/jats:italic>\n                    detected heterogeneity in 5 GM, and MR\u2010Egger intercept suggested directional pleiotropy in 3 GM; all remaining GM showed non\u2010significant sensitivity metrics. Leave\u2010one\u2010out analyses showed no single SNP disproportionately influenced the estimates, reinforcing the stability of the findings. This MR study provides genetic evidence supporting a potential causal association between GM and sleep apnoea. These findings provide new insights that may inform future research and prevention strategies.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.70976","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:06:23Z","timestamp":1767845183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Causal Association Between Gut Microbiota and Sleep Apnoea Identified by Bayesian Weighted Mendelian Randomisation"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0660-3763","authenticated-orcid":false,"given":"Chenguang","family":"Zhang","sequence":"first","affiliation":[{"name":"Graduate School of Qinghai University  Xining China"},{"name":"Department of Otolaryngology Qinghai University Affiliated Hospital  Xining 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